Serum Levels of Subfatin in Patients With Type 2 Diabetes Mellitus and Its Association With Vascular Adhesion Molecules

Serum Levels of Subfatin in Patients With Type 2 Diabetes Mellitus and Its Association With Vascular Adhesion Molecules Publisher Pubmed

Fadaei R¹ ; Dadmanesh M² ; Moradi N^{3, 4} ; Ahmadi R⁵ ; Shokoohi Nahrkhalaji A⁴ ; Aghajani H⁶ ; Ghorban K¹

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1. Department of Immunology, School of Medicine, Aja University of Medical Sciences, Tehran, IR, Iran
2. Department of Infectious Diseases, School of Medicine, Aja University of Medical Sciences, Tehran, IR, Iran
3. Department of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
4. Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
5. Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
6. Interventional Cardiology Department, Tehran Heart Center Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Physiology and Biochemistry Published:2020

Abstract

Subfatin is a newly discovered adipokine with insulin-sensitizing properties. Studies reported conflicting data with regard to the circulating levels and expression of Subfatin in the context of type 2 diabetes mellitus (T2DM) and obesity. The present study was conducted on 52 patients with T2DM, 36 prediabetes subjects, and 50 controls. The serum levels of Subfatin, adhesion molecules were measured by the ELISA technique. The serum Subfatin was lower in the T2DM and prediabetes groups. The serum levels of adhesion molecules were higher in the T2DM group. In addition, Subfatin demonstrated lower levels in obese patients with T2DM in comparison to lean T2DM patients. Furthermore, Subfatin showed a negative association with vascular adhesion molecules in prediabetes subjects and the T2DM group. A decrease in the serum Subfatin in T2DM patients and prediabetes subjects, and its association with vascular adhesion molecules suggested the possible role of Subfatin in diabetes and endothelial dysfunction. © 2018 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Fadaei R, et al.. "Serum Levels of Subfatin in Patients With Type 2 Diabetes Mellitus and Its Association With Vascular Adhesion Molecules." Archives of Physiology and Biochemistry, vol. 126, no. 4, 2020, pp. 335-340.
APA	Fadaei R, Dadmanesh M, Moradi N, Ahmadi R, Shokoohi Nahrkhalaji A, Aghajani H, Ghorban K (2020). Serum Levels of Subfatin in Patients With Type 2 Diabetes Mellitus and Its Association With Vascular Adhesion Molecules. Archives of Physiology and Biochemistry, 126(4), 335-340.
Chicago	Fadaei R, Dadmanesh M, Moradi N, Ahmadi R, Shokoohi Nahrkhalaji A, Aghajani H, Ghorban K. "Serum Levels of Subfatin in Patients With Type 2 Diabetes Mellitus and Its Association With Vascular Adhesion Molecules." Archives of Physiology and Biochemistry 126, no. 4 (2020): 335-340.
Harvard	Fadaei R et al. (2020) 'Serum Levels of Subfatin in Patients With Type 2 Diabetes Mellitus and Its Association With Vascular Adhesion Molecules', Archives of Physiology and Biochemistry, 126(4), pp. 335-340.
Vancouver	Fadaei R, Dadmanesh M, Moradi N, Ahmadi R, Shokoohi Nahrkhalaji A, Aghajani H, et al.. Serum Levels of Subfatin in Patients With Type 2 Diabetes Mellitus and Its Association With Vascular Adhesion Molecules. Archives of Physiology and Biochemistry. 2020;126(4):335-340.
BibTex	@article{ author = {Fadaei R and Dadmanesh M and Moradi N and Ahmadi R and Shokoohi Nahrkhalaji A and Aghajani H and Ghorban K}, title = {Serum Levels of Subfatin in Patients With Type 2 Diabetes Mellitus and Its Association With Vascular Adhesion Molecules}, journal = {Archives of Physiology and Biochemistry}, volume = {126}, number = {4}, pages = {335-340}, year = {2020} }
RIS	TY - JOUR AU - Fadaei R AU - Dadmanesh M AU - Moradi N AU - Ahmadi R AU - Shokoohi Nahrkhalaji A AU - Aghajani H AU - Ghorban K TI - Serum Levels of Subfatin in Patients With Type 2 Diabetes Mellitus and Its Association With Vascular Adhesion Molecules JO - Archives of Physiology and Biochemistry VL - 126 IS - 4 SP - 335 EP - 340 PY - 2020 ER -

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