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The Efficacy of Gabaergic Precursor Cells Transplantation in Alleviating Neuropathic Pain in Animal Models: A Systematic Review and Meta-Analysis Publisher



Askarianamiri S1 ; Maleki SN2 ; Alavi SNR2 ; Neishaboori AM2 ; Toloui A2 ; Gubari MIM3 ; Sarveazad A4, 5 ; Hosseini M6, 7 ; Yousefifard M2
Authors
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Authors Affiliations
  1. 1. Institute de Biologie Structurale (IBS), Grenoble Alpes University, CEA, CNRS, Grenoble, France
  2. 2. Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Family and Community Medicine, College of Medicine, University of Sulaimani, Sulaimani, Iraq
  4. 4. Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Nursing Care Research Center, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Korean Journal of Pain Published:2022


Abstract

Background: Current therapies are quite unsuccessful in the management of neuropathic pain. Therefore, considering the inhibitory characteristics of GABA mediators, the present systematic review and meta-analysis aimed to determine the efficacy of GABAergic neural precursor cells on neuropathic pain management. Methods: Search was conducted on Medline, Embase, Scopus, and Web of Science databases. A search strategy was designed based on the keywords related to GABAergic cells combined with neuropathic pain. The outcomes were allodynia and hyperalgesia. The results were reported as a pooled standardized mean difference (SMD) with a 95% confidence interval (95% CI). Results: Data of 13 studies were analyzed in the present meta-analysis. The results showed that administration of GABAergic cells improved allodynia (SMD = 1.79; 95% CI: 0.87, 271; P < 0.001) and hyperalgesia (SMD = 1.29; 95% CI: 0.26, 2.32; P = 0.019). Moreover, the analyses demonstrated that the efficacy of GABAergic cells in the management of allodynia and hyperalgesia is only observed in rats. Also, only genetically modified cells are effective in improving both of allodynia, and hyperalgesia. Conclusions: A moderate level of pre-clinical evidence showed that transplantation of genetically-modified GABAergic cells is effective in the management of neuropathic pain. However, it seems that the transplantation efficacy of these cells is only statistically significant in improving pain symptoms in rats. Hence, caution should be exercised regarding the generalizability and the translation of the findings from rats and mice studies to large animal studies and clinical trials. © The Korean Pain Society, 2022.
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