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Association of Human Endogenous Retrovirus-W (Herv-W) Copies With Pemphigus Vulgaris Publisher Pubmed



Semsari H1 ; Babaei E1, 2 ; Ranjkesh M3 ; Esmaili N4 ; Mallet F5, 6 ; Karimi A7
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Authors Affiliations
  1. 1. Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
  2. 2. Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq
  3. 3. Department of Dermatology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Razi Hospital, Tehran, Iran
  5. 5. Joint Research Unit Hospices Civils de Lyon-bioMerieux, Lyon Sud Hospital, Pierre-Benite, France
  6. 6. EA 7426 Pathophysiology of Injury-Induced Immunosuppression, Edouard Herriot Hospital, University of Lyon1-Hospices Civils de Lyon-bioMerieux, 5 Place d'Arsonval, Lyon Cedex 3, Lyon, France
  7. 7. Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Current Molecular Medicine Published:2024


Abstract

Background: Pemphigus is classified as a group of chronic, recurrent, and potentially fatal bullous autoimmune diseases that leads to blisters and skin lesions resulting from IgG antibodies and the loss of cellular connections in the epidermis. Human endogenous retrovirus (HERV) sequences and their products (RNA, cytosolic DNA, and proteins) can modulate the immune system and contribute to autoimmunity. The extent to which, HERV-W env copies may be involved in the pathogenesis of pemphigus remains to be elucidated. Aim: This study aimed to comparatively evaluate the relative levels of HERV-W env DNA copy numbers in the peripheral blood mononuclear cells (PBMCs) of pemphigus vulgaris patients and healthy controls. Methods: Thirty-one pemphigus patients and the corresponding age-and sex-matched healthy controls were included in the study. The relative levels of HERV-W env DNA copy numbers were then evaluated by qPCR using specific primers, in the PBMCs of the patients and controls. Results: Our results indicated that relative levels of HERV-W env DNA copy numbers in the patients were significantly higher than that in the controls (1.67±0.86 vs. 1.17±0.75; p = 0.02). There was also a significant difference between the HERV-W env copies of male and female patients (p = 0.001). Furthermore, there was no relationship between the HERV-W env copy number and disease onset (p = 0.19). According to the obtained data, we could not find any relationship between the HERV-W env copy number and serum Dsg1(p=0.86) and Dsg3 (p=0.76) levels. Conclusion: Our results indicated a positive link between the HERV-W env copies and pathogenesis of pemphigus. The association between clinical severity score and HERV-W env copies in the PBMCs as a biomarker for pemphigus needs further studies. © 2024 Bentham Science Publishers.
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