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1H-Mrs Metabolite's Ratios Show Temporal Alternation in Temporal Lobe Seizure: Comparison Between Interictal and Postictal Phases Publisher Pubmed



Fadaie F1 ; Mobarakeh NM2, 3 ; Fesharaki SSH1 ; Harirchian MH4 ; Kharazi HH5 ; Rad HS2, 3 ; Habibabadi JM6
Authors
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Authors Affiliations
  1. 1. Comprehensive Epilepsy Program, Epilepsy Monitoring Unit, Pars Hospital, Tehran, Iran
  2. 2. Quantitative MR Imaging and Spectroscopy Group, Research Center for Molecular and Cellular Imaging, Tehran, Iran
  3. 3. Department of Biomedical Engineering and Medical Physics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Neurology, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Radiology, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Isfahan Neurosciences Research Center, Neurology Department, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Epilepsy Research Published:2016


Abstract

Purposes To determine 1H-MRSI metabolites changes in interictal and postictal phases of patients suffering from mesial temporal lobe epilepsy with hippocampal sclerosis and lateralization of seizure foci. Materials and methods MR spectroscopic imaging was performed in 5 adult patients with refractory temporal lobe epilepsy interictally and immediately after the seizure and in 4 adult control subjects. All patients underwent MR imaging and VideoEEG Monitoring. Results The results showed statistically significant decreases in N-acetylaspartate/Creatine, N-acetylaspartate/Choline and N-acetylaspartate/(creatine + choline) immediately after ictus in ipsilateral hippocampus as compared with control data and contralateral hippocampus of patients while no statistically significant difference was presented in interictal phase. Conclusion The present study clearly indicates 1H-MRS abnormalities following an ictus of temporal lobe epilepsy with metabolite recovery in interictal phase. This finding suggests postictal 1H-MRS as a possible useful tool to assist in lateralizing and localizing of seizure foci in epileptic patients with structural lesions. © 2016 Elsevier B.V.
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Hamidreza Saligheh Rad (2)
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