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Effects of Phytochemicals on Macrophage Cholesterol Efflux Capacity: Impact on Atherosclerosis Publisher Pubmed



Soltani S1 ; Boozari M2 ; Cicero AFG3 ; Jamialahmadi T5, 6 ; Sahebkar A4, 7, 8, 9
Authors
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Authors Affiliations
  1. 1. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Hypertension and Cardiovascular Risk Factors Research Center, Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy
  4. 4. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran
  6. 6. Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Halal Research Center of IRI, FDA, Tehran, Iran
  9. 9. Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland

Source: Phytotherapy Research Published:2021


Abstract

High-density lipoprotein cholesterol (HDL) is the major promoter of reverse cholesterol transport and efflux of excess cellular cholesterol. The functions of HDL, such as cholesterol efflux, are associated with cardiovascular disease rather than HDL levels. We have reviewed the evidence base on the major classes of phytochemicals, including polyphenols, alkaloids, carotenoids, phytosterols, and fatty acids, and their effects on macrophage cholesterol efflux and its major pathways. Phytochemicals show the potential to improve the efficiency of each of these pathways. The findings are mainly in preclinical studies, and more clinical research is warranted in this area to develop novel clinical applications. © 2021 John Wiley & Sons, Ltd.
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