The Association Between Vitamin D Status and Inflammatory Bowel Disease Among Children and Adolescents: A Systematic Review and Meta-Analysis Publisher



Fatahi S^{1, 2} ; Alyahyawi N³ ; Albadawi N⁴ ; Mardali F² ; Dara N¹ ; Sohouli MH⁵ ; Prabahar K⁶ ; Rohani P⁷ ; Koushki N² ; Sayyari A¹ ; Hosseini AH¹ ; Abuzaid A⁸ Show Affiliations
Source: Frontiers in Nutrition Published:2023

Abstract

Aim: Vitamin D deficiency is very common among children with IBD. Since there are conflicting results regarding the association of vitamin D with IBD, we conducted this systematic review to confirm the association of vitamin D with IBD. Methods: We conducted a systematic search in Scopus, Cochrane Library, Web of Science, PubMed, and Google Scholar to find relevant studies. Articles with cross-sectional and case-control designs that reported the association between vitamin D and IBD among children were included. Results: Eventually, 9 studies (with 16 effect sizes) reported the mean and SD or the median and the interquartile range of serum vitamin D levels in both subjects with IBD and control subjects. The random effects meta-analysis revealed that subjects with IBD had −1.159 ng/ml (95% CI: −2.783, 0.464) lower serum vitamin D concentrations compared with their healthy counterparts, but this difference was not significant. A total of 14 studies (with 18 effect sizes) with 2,602 participants provided information for the prevalence of vitamin D deficiency or insufficiency in patients with IBD as 44% (95% CI: 0.34–0.54) with significant heterogeneity noted among studies (p < 0.001; I2 = 97.31%). Conclusion: This systematic and meta-analysis study revealed that vitamin D deficiency was associated with IBD. Longitudinal studies should be conducted in the future to confirm our findings. Large randomized controlled trials assessing the doses of supplementation of vitamin D would provide a better understanding of the association between vitamin D and IBD. Copyright © 2023 Fatahi, Alyahyawi, Albadawi, Mardali, Dara, Sohouli, Prabahar, Rohani, Koushki, Sayyari, Hosseini and Abu-Zaid.