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Effect of Cheese and Casein Phosphopeptide‑Amorphous Calcium Phosphate on Erosive Lesions of Primary Teeth Enamel Following Exposure to Amoxicillin and Ibuprofen Syrups:An in Vitro Study Publisher



Yousefi B1 ; Mehran M1 ; Sadabadi Y2 ; Banakar M1, 3 ; Haghgoo R1
Authors
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Authors Affiliations
  1. 1. Department of Pediatric Dentistry, School of Dentistry, Shahed University, Bojnurd, Iran
  2. 2. Department of Pediatric Dentistry, School of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran
  3. 3. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Dental Research Journal Published:2024


Abstract

Background: The acidic component of liquid medicinal syrups used by pediatric patients may cause erosion and partial demineralization.This study aimed to evaluate the effect of cheese and casein phosphopeptide‑amorphous calcium phosphate (CPP‑ACP) on erosive lesions of primary teeth enamel following exposure to amoxicillin and ibuprofen syrups. Materials and Methods: In this in vitro study, 60 noncarious deciduous molars were used.After measuring the surface microhardness of the samples, they were randomly separated into two groups and immersed in either amoxicillin or ibuprofen for 1 min three times per day. CPP‑ACP, cheese, and artificial saliva were then applied to each of the three subgroups (n = 10).After each immersion time, 10 min of therapy was given. Between treatment intervals, the samples were kept in artificial saliva.The microhardness was remeasured after 1 week. Data were analyzed using SPSS software through repeated‑measures ANOVA (α = 0.05). Results: All samples’ microhardness reduced considerably after immersion in liquid pharmaceuticals (amoxicillin [84.9 kgf/mm2] and ibuprofen [75.1 kgf/mm2]),but increased significantly following exposure to therapeutic solutions.There was no difference between the amoxicillin‑cheese and amoxicillin‑CPP‑ACP subgroups (P = 0.975). A statistically insignificant difference was found between the ibuprofen group and the ibuprofen‑CPP‑ACP subgroup (P = 0.499). Conclusion: As a result, cheese and CPP‑ACP can be utilized to remineralize erosive lesions caused by amoxicillin or ibuprofen exposure. © 2024 Dental Research Journal.