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Effect of Antimicrobial Photodynamic Therapy on the Counts of Salivary Streptococcus Mutans in Children With Severe Early Childhood Caries Publisher Pubmed



Fekrazad R1 ; Seraj B2 ; Chiniforush N3 ; Rokouei M4 ; Mousavi N3 ; Ghadimi S5
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Authors Affiliations
  1. 1. Laser Research Center in Medical Sciences, AJA University of Medical Sciences, Tehran, Iran
  2. 2. Dental Research Center Dental Research Institute, Department of Pediatric dentistry Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Laser Research Center of Dentistry Dental Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pediatric Dentistry School of Dentistry, Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Laser Research Center of Dentistry, Dental Research Institute, Department of Pediatric Dentistry, School of Dentistry, Tehran University of Medical Sciences, North Amirabad St., Tehran, Iran

Source: Photodiagnosis and Photodynamic Therapy Published:2017


Abstract

Background Antimicrobial photodynamic therapy (aPDT) is a novel technique for reduction of pathogenic microorganisms in dentistry. The aim of this study was to evaluate the effects of aPDT on Streptococcus mutans reduction in children with severe early childhood caries. Methods Twenty-two children with severe early childhood caries aged 3–6 years were treated with toluoidine blue O (TBO) for 1 min and irradiated by a Light Emitting Diode (LED; FotoSan, CMS Dental, Denmark) with the exposure time of 150 s. Saliva samples were collected at baseline, 1 h and 7 days after treatment. S. mutans counts were determined using the Dentocult SM Strip mutans. Results The counts of S. mutans in saliva decreased significantly after 1 h (P < 0.001). However, the difference in reduction of S. mutans counts in saliva was not significant between the baseline and 7 days after treatment (P > 0.05). Conclusion aPDT seems to be efficient to reduce salivary S. mutans immediately after treatment in children with severe early childhood caries. However, further research is needed to evaluate different doses and frequency of irradiation in combination with restoring carious teeth to find more durable results. © 2017 Elsevier B.V.
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