Imidazopyridine-Based Kinase Inhibitors As Potential Anticancer Agents: A Review Publisher Pubmed



Peytam F¹ ; Emamgholipour Z¹ ; Mousavi A¹ ; Moradi M¹ ; Foroumadi R² ; Firoozpour L¹ ; Divsalar F³ ; Safavi M⁴ ; Foroumadi A^{1, 3, 5}
Source: Bioorganic Chemistry Published:2023

Abstract

Considering the fundamental role of protein kinases in the mechanism of protein phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has underscored their therapeutic relevance. Imidazopyridines represent versatile scaffolds found in abundant bioactive compounds. Given their structural features, imidazopyridines have possessed pivotal potency to interact with different protein kinases, inspiring researchers to carry out numerous structural variations. In this comprehensive review, we encompass an extensive survey of the design and biological evaluations of imidazopyridine-based small molecules as potential agents targeting diverse kinases for anticancer applications. We describe the structural elements critical to inhibitory potency, elucidating their key structure–activity relationships (SAR) and mode of actions, where available. We classify these compounds into two groups: Serine/threonine and Tyrosine inhibitors. By highlighting the promising role of imidazopyridines in kinase inhibition, we aim to facilitate the design and development of more effective, targeted compounds for cancer treatment. © 2023 Elsevier Inc.