Detection of Herpes Simplex Viruses in the Oral Lesions of Patients With Pemphigus Vulgaris: Is It Diagnostic or Predictive of Disease Severity?

Detection of Herpes Simplex Viruses in the Oral Lesions of Patients With Pemphigus Vulgaris: Is It Diagnostic or Predictive of Disease Severity? Publisher

Kamyab K¹ ; Daneshpazhooh M² ; Zaresharifi N³ ; Ghanadan A¹ ; Shahsiah R⁴ ; Mahmoudi HR² ; Zaresharifi S⁵

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1. Department of Dermatopathology, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Pathology, Guilan University of Medical Sciences, Rasht, Iran
4. Cancer Research Centre, Tehran University of Medical Sciences, Tehran, Iran
5. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Skin Health and Disease Published:2023

Abstract

Background: Some studies emphasise the relationship between the herpes simplex virus (HSV) and pemphigus. Although the possible role of HSV in the pathogenesis of pemphigus and the severity of the disease is obscure, we aimed to evaluate the presence of herpes simplex viruses (HSV 1/2) in the oral lesions of patients with pemphigus vulgaris and also assess its association with disease severity and types of lesions. Methods: A retrospective study was conducted on collected data in the form of collecting paraffin blocks, slides, and relevant pathology reports and referring to patients' medical records. A questionnaire containing details on the degree of skin, scalp, and mucosal involvement (Pemphigus Disease Area Index (PDAI)) was fulfiled. The immunoassay result was also collected to check the anti-desmoglein 3 and 1 antibodies (using ELISA technique). Results: In this study, 52 patients of pemphigus vulgaris with oral lesions (case) and 52 patients with oral lesions not related to the disease (control) were evaluated. HSV1 was detected in 13.5% of oral pemphigus lesions and 1.9% of the control group (p = 0.0598). There were no positive cases of HSV2 in either group. There was no significant association between the positivity of HSV1 and the site of lesions (p = 1.00) or disease severity (p = 0.28). However, we found a strong correlation between the PDAI disease severity score with the titre of the AntiDsg3 antibody (r = 0.487, p = 0.001) and AntiDsg1 antibody (r = 0.309, p = 0.026). Conclusion: This study demonstrated a significant prevalence of HSV1 in oral pemphigus lesions, and acyclovir therapy may play a significant role in managing these patients. However, HSV's role in the pathogenesis of pemphigus vulgaris cannot be clearly determined. © 2023 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.

Style	Citing Format
MLA	Kamyab K, et al.. "Detection of Herpes Simplex Viruses in the Oral Lesions of Patients With Pemphigus Vulgaris: Is It Diagnostic or Predictive of Disease Severity?." Skin Health and Disease, vol. 3, no. 5, 2023, pp. -.
APA	Kamyab K, Daneshpazhooh M, Zaresharifi N, Ghanadan A, Shahsiah R, Mahmoudi HR, Zaresharifi S (2023). Detection of Herpes Simplex Viruses in the Oral Lesions of Patients With Pemphigus Vulgaris: Is It Diagnostic or Predictive of Disease Severity?. Skin Health and Disease, 3(5), -.
Chicago	Kamyab K, Daneshpazhooh M, Zaresharifi N, Ghanadan A, Shahsiah R, Mahmoudi HR, Zaresharifi S. "Detection of Herpes Simplex Viruses in the Oral Lesions of Patients With Pemphigus Vulgaris: Is It Diagnostic or Predictive of Disease Severity?." Skin Health and Disease 3, no. 5 (2023): -.
Harvard	Kamyab K et al. (2023) 'Detection of Herpes Simplex Viruses in the Oral Lesions of Patients With Pemphigus Vulgaris: Is It Diagnostic or Predictive of Disease Severity?', Skin Health and Disease, 3(5), pp. -.
Vancouver	Kamyab K, Daneshpazhooh M, Zaresharifi N, Ghanadan A, Shahsiah R, Mahmoudi HR, et al.. Detection of Herpes Simplex Viruses in the Oral Lesions of Patients With Pemphigus Vulgaris: Is It Diagnostic or Predictive of Disease Severity?. Skin Health and Disease. 2023;3(5):-.
BibTex	@article{ author = {Kamyab K and Daneshpazhooh M and Zaresharifi N and Ghanadan A and Shahsiah R and Mahmoudi HR and Zaresharifi S}, title = {Detection of Herpes Simplex Viruses in the Oral Lesions of Patients With Pemphigus Vulgaris: Is It Diagnostic or Predictive of Disease Severity?}, journal = {Skin Health and Disease}, volume = {3}, number = {5}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Kamyab K AU - Daneshpazhooh M AU - Zaresharifi N AU - Ghanadan A AU - Shahsiah R AU - Mahmoudi HR AU - Zaresharifi S TI - Detection of Herpes Simplex Viruses in the Oral Lesions of Patients With Pemphigus Vulgaris: Is It Diagnostic or Predictive of Disease Severity? JO - Skin Health and Disease VL - 3 IS - 5 SP - EP - PY - 2023 ER -

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