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Diagnostic Approach to the Patients With Suspected Primary Immunodeficiency Publisher Pubmed



Tavakol M1, 2 ; Jamee M3 ; Azizi G1, 4 ; Sadri H1, 2 ; Bagheri Y5 ; Zakidizaji M6 ; Mahdavi FS3 ; Jadidiniaragh F7 ; Tajfirooz S8 ; Kamali AN9 ; Aghamahdi F1, 10 ; Noorian S10 ; Kojidi HT10 ; Mosavian M1, 11 Show All Authors
Authors
  1. Tavakol M1, 2
  2. Jamee M3
  3. Azizi G1, 4
  4. Sadri H1, 2
  5. Bagheri Y5
  6. Zakidizaji M6
  7. Mahdavi FS3
  8. Jadidiniaragh F7
  9. Tajfirooz S8
  10. Kamali AN9
  11. Aghamahdi F1, 10
  12. Noorian S10
  13. Kojidi HT10
  14. Mosavian M1, 11
  15. Matani R11
  16. Dolatshahi E12
  17. Porrostami K8
  18. Elahimehr N8
  19. Fatemiabhari M8
  20. Sharifi L13
  21. Arjmand R14
  22. Haghi S15
  23. Zainaldain H4
  24. Yazdani R4
  25. Shaghaghi M16
  26. Abolhassani H17
  27. Aghamohammadi A4

Source: Endocrine# Metabolic and Immune Disorders - Drug Targets Published:2020


Abstract

Background and Objective: Primary immunodeficiency diseases (PIDs) are a group of more than 350 disorders affecting distinct components of the innate and adaptive immune systems. In this review, the classic and advanced stepwise approach towards the diagnosis of PIDs are simplified and explained in detail. Results: Susceptibility to recurrent infections is the main hallmark of almost all PIDs. However, non-infectious complications attributable to immune dysregulation presenting with lymphoproliferative and/or autoimmune disorders are not uncommon. Moreover, PIDs could be associated with misleading presentations including allergic manifestations, enteropathies, and malignancies. Conclusion: Timely diagnosis is the most essential element in improving outcome and reducing the morbidity and mortality in PIDs. This wouldn’t be possible unless the physicians keep the diagnosis of PID in mind and be sufficiently aware of the approach to these patients. © 2020 Bentham Science Publishers.
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