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Association of Nonalcoholic Fatty Liver Disease and Carotid Media-Intima Thickness: A Systematic Review and a Meta-Analysis Publisher



Khoshbaten M1 ; Maleki SH2 ; Hadad S1 ; Baral A3 ; Rocha AV3 ; Poudel L4 ; Abdshah A3, 5
Authors
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Authors Affiliations
  1. 1. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Pathology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, United States
  4. 4. Nepalgunj Medical College, Banke, Nepalgunj, Nepal
  5. 5. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Health Science Reports Published:2023


Abstract

Introduction: The relationship between cardiovascular disorders and nonalcoholic fatty liver disease (NAFLD) has been extensively studied. To better pool this data and make a more definite conclusion, we performed a meta-analysis to evaluate the association between NAFLD and the thickness of media and intima of carotid artery (CIMT) and cardiovascular disorders. Methods: We searched PubMed, Ovid, Scopus, ProQuest, Web of Science, and the Cochrane Library, and analyzed the pooled data using R studio and the “metafor” package. Results: The final analysis included a total of 59 studies with 16,179 cases and 26,120 control individuals. NAFLD was shown to be associated with an increase of 0.1231 mm (20.6%) in carotid artery intima-media thickness (CIMT) (p = 0.002, 95% confidence interval [CI]: 0.0462–0.2000) in individuals with NAFLD. The prevalence of atherosclerotic plaques in the carotid arteries and the occurrence of NAFLD are significantly correlated, according to a meta-analysis based on 17 distinct studies (p = 0.001, 1.28–1.43, 95% CI, odds ratio = 1.356). Conclusion: Patients with increased CIMT are considerably more likely to have NAFLD. Large prospective investigations are required to corroborate these findings and their prognostic significance, along with the effectiveness of the available interventions. © 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC.
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