Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
The Role of Ugt1a1 Polymorphism in the Management of Colorectal Cancer Publisher



E Babadi ELHAM ; K Roudini KAMRAN ; K Aalipour KIANMEHR ; Ob Alese Olatunji BOLADALE
Authors

Source: Oncology Reviews Published:2025


Abstract

Colorectal cancer is a leading cause of cancer related deaths among patients worldwide, necessitating the development of more effective and tolerable therapies. Topoisomerase I inhibitors such as Irinotecan are integral components of chemotherapy regimens used in the management of colorectal, as well as esophageal, gastric, biliary tract, pancreatic, neuroendocrine, small bowel and anal carcinomas. Efficacy and toxicity of these regimens are however impacted by metabolism via the UGT1A1 pathways. This literature review provides a comprehensive overview of UGT1A1 polymorphism in patients with colorectal cancer, including recent developments and the future landscape. Recent literature elucidating the roles of oncogenes and predictive biomarkers on anti-cancer drugs and UGT1A1 genotypes are described. The lack of consensus in the clinical management of patients with colorectal cancer were also explored in depth. A comprehensive search was performed in multiple databases (including PubMed, Embase, Web of Science, Scopus, Research gate, and Google Scholar) to identify relevant articles published up to January 2024. A total of 79 clinical studies were included in this review. The epidemiology and frequency of UGT1A1 genes polymorphisms by race, gender, ethnicity, geographic location and stage of the cancer were correlated with drug metabolism, toxicity, and survival outcomes. The tole of UGT1A1 as a prognostic and predictive biomarker, including existing challenges in clinical application were also discussed extensively. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Prediction of Response to Irinotecan and Drug Toxicity Based on Pharmacogenomics Test: A Prospective Case Study in Advanced Colorectal Cancer, Asian Pacific Journal of Cancer Prevention (2017)
2. Comprehensive Analysis of the Role of Ubiquitin-Specific Peptidases in Colorectal Cancer: A Systematic Review, World Journal of Gastrointestinal Oncology (2024)
3. Key Genes and Regulatory Networks Involved in the Initiation, Progression and Invasion of Colorectal Cancer, Future Science OA (2018)
Experts (# of related papers)
View all Related Experts
Mohsen Esfandbod (2)
Saeid Amanpour (1)
Other Related Docs
4. Association Between Cdkn1a Gene Rs1801270 Polymorphisms and Susceptibility to Colorectal Cancser in an Iranian Population, Nucleosides# Nucleotides and Nucleic Acids (2023)
5. Signal Transduction Pathway Mutations in Gastrointestinal (Gi) Cancers: A Systematic Review and Meta-Analysis, Scientific Reports (2020)
6. Hif-1Α Gene/Protein and Oxidative Stress in Patients With Colorectal Cancer: A Pilot Study, Gene Reports (2023)
7. High Frequency of Microsatellite Instability Among Non-Metastatic Gastric Cancer, International Journal of Hematology-Oncology and Stem Cell Research (2022)
8. Efficacy and Safety of Proposed Bevacizumab Biosimilar Be1040v in Patients With Metastatic Colorectal Cancer: A Phase Iii, Randomized, Double-Blind, Noninferiority Clinical Trial, Clinical Therapeutics (2020)
9. Silencing the Wild-Type and Mutant K-Ras Increases the Resistance to 5-Flurouracil in Hct-116 As a Colorectal Cancer Cell Line, Anti-cancer drugs (2015)
10. Comprehensive Analysis Identifies Endocrine Fibroblast Growth Factors As Promising Prognostic Markers for Colorectal Carcinoma, Scientific Reports (2024)
11. Association of Dna Repair Gene Variants With Colorectal Cancer: Risk, Toxicity, and Survival, BMC Cancer (2020)
12. Gly972arg Variant of Insulin Receptor Substrate 1 Gene and Colorectal Cancer Risk in Overweight/ Obese Subjects, International Journal of Biological Markers (2016)
13. Methylation in Colorectal Cancer, Epigenetics Territory and Cancer (2015)
14. In Silico Identification of the Specific Pathways in Each Stage of Colorectal Cancer and the Association of Their Top Genes With Drug Resistance and Sensitivity, Medical Oncology (2022)
15. Exploring the Relationship Between Kras, Nras, and Braf Mutations and Clinical Characteristics in Iranian Colorectal Cancer Patients, Journal of Gastrointestinal Cancer (2024)
16. Alternative Splicing of the Occ-1 Gene Generates Three Splice Variants and a Novel Exonic Microrna, Which Regulate the Wnt Signaling Pathway, RNA (2017)
17. Advances in Blood Dna Methylation-Based Assay for Colorectal Cancer Early Detection: A Systematic Updated Review, Gastroenterology and Hepatology from Bed to Bench (2024)
18. Inhibition of Ire1 Rnase Activity Modulates Tumor Cell Progression and Enhances the Response to Chemotherapy in Colorectal Cancer, Medical Oncology (2023)
19. A Systematic Review of the Therapeutic Effects of Resveratrol in Combination With 5-Fluorouracil During Colorectal Cancer Treatment: With a Special Focus on the Oxidant, Apoptotic, and Anti-Inflammatory Activities, Cancer Cell International (2022)
20. Identification of Antisense and Sense Rnas of Intracrine Fibroblast Growth Factor Components As Novel Biomarkers in Colorectal Cancer and in Silico Studies for Drug and Nanodrug Repurposing, Environmental Research (2023)