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Dendrosomal Curcumin Inhibits Metastatic Potential of Human Sw480 Colon Cancer Cells Through Down-Regulation of Claudin1, Zeb1 and Hef1-1 Gene Expression Publisher Pubmed



Esmatabadi MJD1 ; Farhangi B1 ; Safari Z2 ; Kazerooni H3 ; Shirzad H4 ; Zolghadr F1 ; Sadeghizadeh M1
Authors
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Authors Affiliations
  1. 1. Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. Genetics Group, Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Chemical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
  4. 4. Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: Asian Pacific Journal of Cancer Prevention Published:2015


Abstract

Colon cancer is one of the leading causes of cancer-associated death worldwide. The prognosis for advanced colorectal cancers remains dismal, mainly due to the propensity for metastatic progression. Accordingly, there is a need for effective anti-metastasis therapeutic agents. Since a great body of research has indicated anticancer effects for curcumin, we investigated the effects of dendrosomal curcumin (DNC) on cellular migration and adhesion of human SW480 cells and possible molecular mechanisms involved. Different methods were applied in this study including MTT, Scratch and adhesion assays as well as real-time PCR and transwell chamber assays. Based on the results obtained, DNC inhibits metastasis by decreasing Hef 1, Zeb 1 and Claudin 1 mRNA levels and can reduce SW480 cell proliferation with IC50 values of 15.9, 11.6 and 7.64 μM at 24, 48 and 72h post-treatment. Thus it might be considered as a safe formulation for therapeutic purpose in colorectal cancer cases.
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