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Carboplatin Liposomal Nanoparticles: Preparation, Characterization, and Cytotoxicity Effects on Lung Cancer in Vitro Environment Publisher



Poy D1 ; Ebrahimi Shahemabadi H2 ; Akbarzadeh A1 ; Moradisardareh H3 ; Ebrahimifar M4
Authors

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2018


Abstract

The study aimed to encapsulate anticancer drug carboplatin into liposomal nanoparticles by reverse-phase evaporation technique and evaluate its efficacy on lung cancer in vitro environment. Nanoparticles were characterized in terms of size, drug loading efficiency, drug retention capability, and cytotoxicity effects. Nanoscale particles with 67% drug encapsulation efficiency were prepared. Also, high retention capability (drug release equal to 25% after 72 h) of the nanodrug was confirmed. In addition, results of the nanodrug cytotoxicity indicated nanoparticles increased potency of the drug by approximately 90%. Findings of the study indicated liposome can be used for carboplatin delivery to lung cancer. © 2017 Taylor & Francis.
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