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Trichophyton Mentagrophytes and T Interdigitale Genotypes Are Associated With Particular Geographic Areas and Clinical Manifestations Publisher Pubmed



Taghipour S1 ; Pchelin IM2 ; Zarei Mahmoudabadi A1 ; Ansari S3 ; Katiraee F4 ; Rafiei A1 ; Shokohi T5 ; Abastabar M5 ; Taraskina AE2 ; Kermani F5 ; Diba K6 ; Nouripoursisakht S7 ; Najafzadeh MJ8 ; Pakshir K9 Show All Authors
Authors
  1. Taghipour S1
  2. Pchelin IM2
  3. Zarei Mahmoudabadi A1
  4. Ansari S3
  5. Katiraee F4
  6. Rafiei A1
  7. Shokohi T5
  8. Abastabar M5
  9. Taraskina AE2
  10. Kermani F5
  11. Diba K6
  12. Nouripoursisakht S7
  13. Najafzadeh MJ8
  14. Pakshir K9
  15. Zomorodian K9
  16. Ahmadikia K10
  17. Rezaeimatehkolaei A1
Show Affiliations
Authors Affiliations
  1. 1. Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Kashkin Research Institute of Medical Mycology, North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russian Federation
  3. 3. Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
  5. 5. Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Cellular and Molecular Research Center, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  7. 7. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  8. 8. Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Basic Sciences in Infectious Diseases Research Center, Parasitology & Mycology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  10. 10. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Mycoses Published:2019


Abstract

The fungi Trichophyton mentagrophytes and T interdigitale account for significant amount of dermatophytosis cases worldwide. These two dermatophytes form a species complex and have a number of ribosomal internal transcribed spacer (ITS) region genotypes, allowing simultaneous species identification and strain typing. Our aim was to describe the geographic distribution of T mentagrophytes/T interdigitale ITS region genotypes and find an association between the genotypes and clinical presentations of respective infections. We performed rDNA ITS region sequencing in 397 Iranian T mentagrophytes/T interdigitale isolates and analysed all available in GenBank entries with sequences of this kind. For the study, 515 clinical annotations were available. Statistical analysis was performed by chi-squared test and Spearman rank correlation analysis. A total of 971 sequences belonged to genotypes with at least 10 geographic annotations and were classified on the basis of exclusive occurrence in a particular region or high relative contribution to a regional sample. We discerned Asian and Oceanian (“KU496915” Type V, “KT192500” Type VIII, “KU315316”), European (“FM986750” Type III, “MF926358” Type III*, “KT285210” Type VI) and cosmopolitan (“FM986691” Type I, “JX122216” Type II, “KP132819” Type II* and “AF170453” Type XXIV) genotypes. There was statistically significant difference in the ITS genotype distribution between different affected body sites. Trichophyton mentagrophytes “KT192500” Type VIII correlated with tinea cruris, T mentagrophytes “KU496915” Type V correlated with tinea corporis, T interdigitale “JX122216” Type II correlated with tinea pedis and onychomycosis. Trichophyton mentagrophytes and T interdigitale genotypes can be associated with distinct geographic locations and particular clinical presentations. © 2019 Blackwell Verlag GmbH
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