The Effect of Vitamin D on Anti-Hiv Micrornas and Hiv Replication in Vitro Model

The Effect of Vitamin D on Anti-Hiv Micrornas and Hiv Replication in Vitro Model Publisher

Yousefi M¹ ; Mollaeikandelous Y² ; Tabatabaie H¹ ; Marashi SM³ ; Nejati A³

Show Affiliations

1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2. Immunology Department, Iran University of Medical Science, Tehran, Iran
3. Department of Virology, International Campus, Tehran University of Medical Sciences, Tehran, Iran

Source: Molecular Genetics# Microbiology and Virology Published:2020

Abstract

Abstract: The active form of vitamin D, 1α,25-Dihydroxyvitamin D3, induced proteins expression that associated with anti-HIV activity. Moreover, several studies have reported that some microRNAs inhibit HIV replication by targeting 3' LTR HIV mRNAs designated anti-HIV microRNAs. To date, the effect of 1α,25-Dihydroxyvitamin D3 (1,25(OH)2D3) on anti-HIV microRNAs expression is unknown. We aimed to determine whether 1,25(OH)2D3 effects of anti-HIV microRNAs expression and inhibit of HIV replication. microRNAs expression were analyzed by stem-loop RT-PCR in jurkat cell line and PBMC culture system. HIV production was examined by ELISA method. Our results show that 1,25(OH)2D3 no effect on anti-HIV microRNAs expression in both jurkat cell line and PBMC culture system. Moreover, CD4 T cells could not be reduce HIV-1 production which treated by 1,25(OH)2D3. All these data may contribute to the mechanism of 1,25(OH)2D3 on virus infection. © 2020, Allerton Press, Inc.

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Style	Citing Format
MLA	Yousefi M, et al.. "The Effect of Vitamin D on Anti-Hiv Micrornas and Hiv Replication in Vitro Model." Molecular Genetics# Microbiology and Virology, vol. 35, no. 3, 2020, pp. 189-193.
APA	Yousefi M, Mollaeikandelous Y, Tabatabaie H, Marashi SM, Nejati A (2020). The Effect of Vitamin D on Anti-Hiv Micrornas and Hiv Replication in Vitro Model. Molecular Genetics# Microbiology and Virology, 35(3), 189-193.
Chicago	Yousefi M, Mollaeikandelous Y, Tabatabaie H, Marashi SM, Nejati A. "The Effect of Vitamin D on Anti-Hiv Micrornas and Hiv Replication in Vitro Model." Molecular Genetics# Microbiology and Virology 35, no. 3 (2020): 189-193.
Harvard	Yousefi M et al. (2020) 'The Effect of Vitamin D on Anti-Hiv Micrornas and Hiv Replication in Vitro Model', Molecular Genetics# Microbiology and Virology, 35(3), pp. 189-193.
Vancouver	Yousefi M, Mollaeikandelous Y, Tabatabaie H, Marashi SM, Nejati A. The Effect of Vitamin D on Anti-Hiv Micrornas and Hiv Replication in Vitro Model. Molecular Genetics# Microbiology and Virology. 2020;35(3):189-193.
BibTex	@article{ author = {Yousefi M and Mollaeikandelous Y and Tabatabaie H and Marashi SM and Nejati A}, title = {The Effect of Vitamin D on Anti-Hiv Micrornas and Hiv Replication in Vitro Model}, journal = {Molecular Genetics# Microbiology and Virology}, volume = {35}, number = {3}, pages = {189-193}, year = {2020} }
RIS	TY - JOUR AU - Yousefi M AU - Mollaeikandelous Y AU - Tabatabaie H AU - Marashi SM AU - Nejati A TI - The Effect of Vitamin D on Anti-Hiv Micrornas and Hiv Replication in Vitro Model JO - Molecular Genetics# Microbiology and Virology VL - 35 IS - 3 SP - 189 EP - 193 PY - 2020 ER -

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