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The Effectiveness of Single-Dose Azithromycin Versus Its Combination With Moxifloxacin Based on the Treatment of Chlamydial Cervicitis: A Study Protocol for a Randomized Clinical Trial Publisher



Mohammadzadeh F1 ; Dolatian M2 ; Jorjani M3 ; Afrakhteh M4 ; Majd HA5 ; Qorbani M6, 7
Authors
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Authors Affiliations
  1. 1. Department of Midwifery & Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Midwifery & Reproductive Health, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Obstetrics and gynaecology, Tajrish Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biostatistics, Paramedical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  7. 7. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Women's Health and Reproduction Sciences Published:2019


Abstract

Objectives: Chlamydia trachomatis is globally reported as a pathogenic infection and is the most common bacterial cause of sexually transmitted infection (STI) in most countries. In addition, chlamydial cervicitis and the adverse complications of the first line treatment, namely, azithromycin failure are highly prevalent. Thus, the present study will be conducted to determine and compare the effects of single-dose azithromycin and its combination with moxifloxacin based on syndromic and etiologic methods in the diagnosis and treatment of chlamydial cervicitis. Materials and Methods: This is a study protocol for a randomized clinical trial which will be performed at the Women’s Clinics and Health Centers in Amol, Iran during 2018. Further, the study will evaluate women with cervicitis complaints, who have a proven case of chlamydial cervicitis through syndromic or etiologic diagnostic methods and meet the inclusion criteria for the study population. Discussion: To the best of our knowledge, this trial will be the first study to explore the effects of single-dose azithromycin in combination with moxifloxacin in the treatment of chlamydial cervicitis. The results of this trial will further reveal the diagnostic value of syndromic and etiologic methods in the diagnosis of chlamydial cervicitis. © 2019 The Author(s).
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