Association of the High-Sensitive Cardiac Troponin T Levels and Long-Term Mortality in Patients With Acute Aortic Dissection Type A Publisher



Jenab Y¹ ; Ahmaditafti SH² ; Davarpasand T¹ ; Jalali A¹ ; Khederlou H¹ Show Affiliations
Source: Journal of Cardiovascular and Thoracic Research Published:2023

Abstract

Introduction: Acute aortic dissection type A is a life-threatening cardiovascular emergency necessitating rapid diagnosis and treatment. We sought a new prognostic tool with cardiac biomarkers and simple inflammatory factors. Methods: from 2003 to 2014, 50 patients with documented acute aortic dissection type A were entered to this study. These patients were followed up until December 2020; within median follow up of 93.6 months. The patients were evaluated on the association of the baseline characteristics, first laboratory investigation, echocardiographic findings, surgical approach, and long-term mortality. Results: Total number of mortality during the follow up was 29 (58%) patients, which was significantly higher in medical group (89.4% vs 38.7%, P value = 0.001). Multivariable analysis showed only an increase in hs-cTnT levels was suggested as a predictor of mortality (95% CI: 1.06-1.38; HR = 1.21; P = 0.005), so that for every 100 units increase, patients were 21% more likely to have mortality in long term. Also, performing surgical treatment for aortic dissection was determined as the independent predictor of surviving, so that death was 74.6% less than those who received medical treatment (95% CI: 0.13-0.58; HR = 0.27; P = 0.001). Conclusion: hs-cTnT is a potential predictor of mortality in patients with acute aortic dissection type A. © 2023 The Author(s).