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Prevention of Hemodialysis Catheter-Related Blood Stream Infections Using a Cotrimoxazole-Lock Technique Publisher Pubmed



Moghaddas A1 ; Abbasi MR2 ; Gharekhani A3 ; Dashtikhavidaki S2 ; Razeghi E2 ; Jafari A1 ; Khalili H1
Authors
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Authors Affiliations
  1. 1. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Nephrology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Future Microbiology Published:2015


Abstract

Background & aim: This trial assessed the efficacy of cotrimoxazole lock solution in reducing catheter-related blood stream infections (CRBSIs) among hemodialysis (HD) patients who were dialyzed using tunneled catheters. Method: Patients randomly received either heparin (2500 U/ml) (control group) or a mixture of 10 mg/ml cotrimoxazole (based on trimethoprim) and 2500 U/ml heparin (antibiotic group) as catheters lock solution. Results: Compared with the control group, CRBSIs rates per 1000 catheter-days was significantly lower (0.58 vs 4.4 events; p = 0.002) and cumulative infection-free catheter survival was significantly higher (log rank statistic 5.88; p = 0.015) in the antibiotic group. There were no statistical differences regarding incidences of catheter removal (8.7% in the antibiotic group vs 22% in the control group; p = 0.116) or thrombosis (2.2% in the antibiotic group vs 9.8% in the control group; p = 0.129) between the two groups. Conclusion: cotrimoxazole containing catheter lock solution is effective in reducing CRBSIs incidence and prolonging dialysis catheter survival in HD patients. © 2015 Future Medicine Ltd.