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Effect of Omega-3 Fatty Acids Supplementation on Muscle Mass, Fat Mass, and Visceral Fat of Hemodialysis Patients; a Randomized Clinical Trial Publisher Pubmed



Torki SA1 ; Roumi Z2 ; Tahavorgar A3 ; Salimi Z4 ; Mohammadi S5 ; Shekari S2 ; Saeedirad Z6 ; Amjadi A7 ; Mirzaee P8 ; Shafaei H9 ; Bahar B10 ; Mofidi F6 ; Khosravi M11 ; Doaei S12, 13 Show All Authors
Authors
  1. Torki SA1
  2. Roumi Z2
  3. Tahavorgar A3
  4. Salimi Z4
  5. Mohammadi S5
  6. Shekari S2
  7. Saeedirad Z6
  8. Amjadi A7
  9. Mirzaee P8
  10. Shafaei H9
  11. Bahar B10
  12. Mofidi F6
  13. Khosravi M11
  14. Doaei S12, 13
  15. Gholamalizadeh M14
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, Faculty of Nutrition Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Zanjan University of Medical Sciences, Zanjan, Iran
  6. 6. Department of Clinical Nutrition and Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Nutrition, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  8. 8. Department of Medicine, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  9. 9. Shahid Beheshti College of Midwifery, Guilan University of Medical Sciences, Rasht, Iran
  10. 10. Nutrition Sciences and Applied Food Safety Studies, Research Centre for Global Development, School of Sport & Health Sciences, University of Central Lancashire, Preston, United Kingdom
  11. 11. Urology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  12. 12. Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  13. 13. Reproductive Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
  14. 14. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Basic and Clinical Physiology and Pharmacology Published:2024


Abstract

Objectives: Several studies demonstrated the benefits of omega-3 fatty acids supplementation in chronic kidney disease (CKD) patients. The objective of this study was to investigate the effect of omega-3 fatty acids supplementation in body composition, specifically on the lean body mass and fat mass in hemodialysis patients. Methods: In this randomized, double-blind, placebo-controlled clinical trial, a total of 120 end-stage renal disease (ESRD) patients were randomly allocated into two groups. The intervention group has taken three grams of omega-3 fatty acids daily while the placebo group received three grams of medium chain triglycerides (MCT) as a placebo for a total of 2 months. The changes in the body mass index (BMI) and body composition (fat mass, muscle, and visceral fat) were assessed at baseline and following the intervention. Results: No significant difference was found in the mean of BMI, FAT, muscle, and visceral fat in the intervention group compared to the control group after the intervention. After two months of omega-3 fatty acid supplementation, the study found no statistically significant impact of omega-3 fatty acids supplementation on various indices of body composition. The effect of ω-3 supplementation in reducing visceral fat was close to significant (p=0.08). Conclusions: This study suggests that there is currently inadequate evidence to support the effect of omega-3 fatty acid supplementation in improving anthropometric measurements in patients with CKD, except a partial effect on visceral fat. Further large-scale and long-term clinical trials are needed to confirm the present results. © 2024 Walter de Gruyter GmbH. All rights reserved.
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