Effect of the Omega-3 Fatty Acid Plus Vitamin E Supplementation on Subjective Global Assessment Score, Glucose Metabolism, and Lipid Concentrations in Chronic Hemodialysis Patients Publisher Pubmed



Asemi Z¹ ; Soleimani A² ; Bahmani F¹ ; Shakeri H¹ ; Mazroii N¹ ; Abedi F¹ ; Fallah M¹ ; Mohammadi AA¹ ; Esmaillzadeh A^{3, 4, 5} Show Affiliations
Source: Molecular Nutrition and Food Research Published:2016

Abstract

Scope: This study was conducted to determine the effects of omega-3 fatty acid plus vitamin E supplementation on subjective global assessment (SGA) score and metabolic profiles in chronic hemodialysis (HD) patients. Methods and results: This randomized double-blind placebo-controlled clinical trial was conducted among 120 chronic HD patients. Participants were randomly divided into four groups to receive: (i) 1250 mg/day omega-3 fatty acid containing 600 mg eicosapentaenoic acid and 300 mg docosahexaenoic acid + vitamin E placebo (n = 30), (ii) 400 IU/day vitamin E + omega-3 fatty acids placebo (n = 30), (iii) 1250 mg omega-3 fatty acids/day + 400 IU/day vitamin E (n = 30), and (iv) omega-3 fatty acids placebo + vitamin E placebo (n = 30) for 12 wk. Fasting blood samples were taken at baseline and after 12-wk intervention to measure metabolic profiles. Patients who received combined omega-3 fatty acids and vitamin E supplements compared with vitamin E, omega-3 fatty acids, and placebo had significantly decreased SGA score (p < 0.001), fasting plasma glucose (p = 0.01), serum insulin levels (p = 0.001), homeostasis model of assessment insulin resistance (p = 0.002), and improved quantitative insulin sensitivity check index (p = 0.006). Conclusion: Omega-3 fatty acids plus vitamin E supplementation for 12 wk among HD patients had beneficial effects on SGA score and metabolic profiles. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.