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Cardiorespiratory Fitness, Perceived Fitness and Autonomic Function in In-Patients With Different Depression Severity Compared With Healthy Controls Publisher Pubmed



Kreppke JN1 ; Cody R1 ; Beck J2 ; Brand S1, 3, 4, 5, 6 ; Donath L7 ; Eckert A3 ; Imboden C8, 9 ; Hatzinger M10 ; Holsboertrachsler E3 ; Lang UE3 ; Mans S8 ; Mikoteit T10 ; Oswald A2 ; Rogausch A2 Show All Authors
Authors
  1. Kreppke JN1
  2. Cody R1
  3. Beck J2
  4. Brand S1, 3, 4, 5, 6
  5. Donath L7
  6. Eckert A3
  7. Imboden C8, 9
  8. Hatzinger M10
  9. Holsboertrachsler E3
  10. Lang UE3
  11. Mans S8
  12. Mikoteit T10
  13. Oswald A2
  14. Rogausch A2
  15. Schweinfurthkeck N3
  16. Zahner L1
  17. Gerber M1
  18. Faude O1
Show Affiliations
Authors Affiliations
  1. 1. Department for Sport, Exercise and Health, University of Basel, Basel, Switzerland
  2. 2. Psychiatric Clinic Sonnenhalde, Riehen, Switzerland
  3. 3. Adult Psychiatric Clinics (UPKE), University of Basel, Basel, Switzerland
  4. 4. Substance Use Prevention Research Center and Sleep Disorder Research Center, Kermanshah University of Medical Sciences (KUMS), Kermanshah, 6715847141, Iran
  5. 5. School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  6. 6. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6719851115, Iran
  7. 7. German Sport University Cologne, Department of Intervention Research in Exercise Training, Cologne, Germany
  8. 8. Private Clinic Wyss, Munchenbuchsee, Switzerland
  9. 9. University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland
  10. 10. Psychiatric Services, Solothurn, and Medical Faculty, University of Basel, Switzerland

Source: Journal of Psychiatric Research Published:2024


Abstract

Over 300 million individuals worldwide suffer from major depressive disorder (MDD). Individuals with MDD are less physically active than healthy people which results in lower cardiorespiratory fitness (CRF) and less favorable perceived fitness compared with healthy controls. Additionally, individuals with MDD may show autonomic system dysfunction. The purpose of the present study was to evaluate the CRF, perceived fitness and autonomic function in in-patients with MDD of different severity compared with healthy controls. We used data from 212 in-patients (age: 40.7 ± 12.6 y, 53% female) with MDD and from 141 healthy controls (age: 36.7 ± 12.7 y, 58% female). We assessed CRF with the Astrand-Rhyming test, self-reported perceived fitness and autonomic function by heart rate variability (HRV). In specific, we used resting heart rate, time- and frequency-based parameters for HRV. In-patients completed the Beck Depression Inventory-II (BDI-II) to self-assess the subjectively rated severity of depression. Based on these scores, participants were grouped into mild, moderate and severe MDD. The main finding was an inverse association between depression severity and CRF as well as perceived fitness compared with healthy controls. Resting heart rate was elevated with increasing depression severity. The time-based but not the frequency-based autonomic function parameters showed an inverse association with depression severity. The pattern of results suggests that among in-patients with major depressive disorder, those with particularly high self-assessed severity scores show a lower CRF, less favorable perceived fitness and partial autonomic dysfunction compared to healthy controls. To counteract these conditions, physical activity interventions may be effective. © 2024 The Authors
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