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Investigating the Effectiveness of Intraoperative Rapid Parathyroid Hormone Assay in Parathyroidectomy Surgery in Patients With Secondary Hyperparathyroidism Publisher Pubmed



Nasiri S1 ; Meshkati Yazd SM1 ; Heshmati A1 ; Mokhtari Ardekani A2 ; Najafi M1 ; Shahriarirad R3, 4
Authors
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Authors Affiliations
  1. 1. Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Science, & Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Science, Shiraz, Iran

Source: BMC Endocrine Disorders Published:2023


Abstract

Introduction: The use of Rapid Intraoperative parathyroid hormone (Io-PTH) assay during surgery in the management of parathyroid tissue in cases of primary hyperparathyroidism has been proven to be effective, while its utilization in secondary hyperparathyroidism (SHPT) has been rarely reported. In the present study, we aim to demonstrate the application of rapid Io-PTH assay in patients with SHPT following chronic kidney disease undergoing parathyroidectomy surgery. Method: In this prospective study, five blood samples were taken from patients undergoing parathyroidectomy and upper thymectomy. Among the samples, two were pre-excision, including prior to the first incision, after exploration, and before parathyroids resection. Two additional samples were taken 10 and 20 min after the excision of the parathyroid glands. Another sample was collected twenty-four hours after the operation. Serum Calcium levels and PTH levels were evaluated and analyzed. Results: We successfully managed SHPT in all 36 patients in our study. The patients included 24 males (66.7%) with a mean age of 49.97 ± 14.92. The mean PTH decreased significantly at 10 min, 20 min, one day, and six months after surgery (P < 0.001). The highest reduction occurred 10 min after removal of the parathyroid glands so the mean PTH compared to time zero was reduced from 1737 to 439, and in 100% of cases, more than 50% reduction was seen in PTH. Conclusion: A 60% or more reduction in PTH Rapid at 10 min after parathyroidectomy has an accuracy of 94.4% and a positive predictive value of 100%. Thus, if the PTH level does not decrease by more than 60% at 10 min or more than 80% at 20 min, tissue exploration is continued with the aim of finding the ectopic parathyroid gland. © 2023, The Author(s).
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1. Autotransplantation of Parathyroid Tissue Into Subcutaneous Subclavicular Area Following Total Parathyroidectomy in Secondary Hyperparathyroidism, Journal of Endocrinological Investigation (2022)
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Shirzad Nasiri (1)