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Who Guidance on Covid-19 Vaccine Trial Designs in the Context of Authorized Covid-19 Vaccines and Expanding Global Access: Ethical Considerations Publisher Pubmed



Singh JA1, 2, 3 ; Kochhar S4, 5 ; Wolff J6 ; Atuire C7 ; Bhan A8 ; Emanuel E9 ; Faden R10 ; Ghimire P11 ; Greco D12 ; Ho C13 ; Moon S14 ; Shamsigooshki E15 ; Toure A16 ; Thome B17 Show All Authors
Authors
  1. Singh JA1, 2, 3
  2. Kochhar S4, 5
  3. Wolff J6
  4. Atuire C7
  5. Bhan A8
  6. Emanuel E9
  7. Faden R10
  8. Ghimire P11
  9. Greco D12
  10. Ho C13
  11. Moon S14
  12. Shamsigooshki E15
  13. Toure A16
  14. Thome B17
  15. Smith MJ18
  16. Upshur REG19
Show Affiliations
Authors Affiliations
  1. 1. Howard College School of Law, University of KwaZulu-Natal, Durban, South Africa
  2. 2. Scientific Advisory Group on Emergencies (SAGE), Academy of Science of South Africa (ASSAf), Pretoria, South Africa
  3. 3. Department of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
  4. 4. Department of Global Health, University of Washington, Seattle, WA, United States
  5. 5. Global Healthcare Consulting, Delhi, India
  6. 6. Blavatnik School of Government, University of Oxford, UK, Oxford, United Kingdom
  7. 7. Department of Philosophy and Classics, University of Ghana, Accra, Ghana
  8. 8. Department of Community Medicine and Centre for Ethics, Yenepoya University, Mangalore, India
  9. 9. Global Initiatives and Healthcare Transformation Institute, University of Pennsylvania, Philadelphia, PA, United States
  10. 10. Johns Hopkins Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, United States
  11. 11. Tribhuvan University, Kirtipur, Nepal
  12. 12. School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
  13. 13. Faculty of Law and Centre for Medical Ethics, University of Hong Kong, Hong Kong Special Administrative Region, China
  14. 14. International Relations and Political Science Department & Interdisciplinary Programmes, Global Health Centre, Graduate Institute of International and Development Studies, Geneva, Switzerland
  15. 15. Department of Medical Ethics, Tehran University of Medical Sciences, Tehran, Iran
  16. 16. Institut Pasteur, Dakar, Senegal
  17. 17. Departamento de Medicina Preventiva, Universidade Federal de Sao Paulo, Rua Botucatu, Sao Paolo, Brazil
  18. 18. Faculty of Health Sciences, Western University, London, ON, Canada
  19. 19. Department of Family and Community Medicine and Dalla Lana School of Public, Health University of Toronto, Toronto, ON, Canada

Source: Vaccine Published:2022


Abstract

While the degree of COVID-19 vaccine accessibility and uptake varies at both national and global levels, increasing vaccination coverage raises questions regarding the standard of prevention that ought to apply to different settings where COVID-19 vaccine trials are hosted. A WHO Expert Group has developed guidance on the ethical implications of conducting placebo-controlled trials in the context of expanding global COVID-19 vaccine coverage. The guidance also considers alternative trial designs to placebo controlled trials in the context of prototype vaccines, modified vaccines, and next generation vaccines. © 2022
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