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Evidence-Based Guidelines for the Pharmacological Treatment of Migraine Publisher Pubmed



Ornello R1 ; Caponnetto V2 ; Ahmed F3 ; Alkhazali HM4 ; Ambrosini A5 ; Ashina S6, 7 ; Baraldi C8 ; Bellotti A9 ; Brighina F10 ; Calabresi P11 ; Casillo F13 ; Cevoli S14 ; Cheng S15 ; Chiang CC16 Show All Authors
Authors
  1. Ornello R1
  2. Caponnetto V2
  3. Ahmed F3
  4. Alkhazali HM4
  5. Ambrosini A5
  6. Ashina S6, 7
  7. Baraldi C8
  8. Bellotti A9
  9. Brighina F10
  10. Calabresi P11
  11. Casillo F13
  12. Cevoli S14
  13. Cheng S15
  14. Chiang CC16
  15. Chiarugi A17
  16. Christensen RH4, 7
  17. Chu MK18
  18. Coppola G13
  19. Corbelli I9
  20. Crema S19
  21. De Icco R20, 21
  22. De Tommaso M22
  23. Di Lorenzo C13
  24. Di Stefano V10
  25. Diener HC23
  26. Ekizoglu E24
  27. Fallacara A25
  28. Favoni V14
  29. Garces KN26
  30. Geppetti P17, 27
  31. Goicochea MT19
  32. Granato A28
  33. Granella F29
  34. Guerzoni S8
  35. Ha WS30
  36. Hassan A31
  37. Hirata K32
  38. Hoffmann J33
  39. Hussler EM34
  40. Hussein M35
  41. Iannone LF17
  42. Jenkins B36
  43. Labastidaramirez A37
  44. Laporta A22
  45. Levin M39
  46. Lupica A10
  47. Mampreso E40
  48. Martinelli D20
  49. Monteith TS25
  50. Orologio I41
  51. Ozge A42
  52. Pan LLH43
  53. Panneerchelvam LL3
  54. Peres MFP44
  55. Souza MNP45
  56. Pozorosich P46
  57. Prudenzano MP25
  58. Quattrocchi S14
  59. Rainero I48
  60. Romanenko V49
  61. Romozzi M11
  62. Russo A41
  63. Sances G20
  64. Sarchielli P9
  65. Schwedt TJ50
  66. Silvestro M41
  67. Swerts DB51
  68. Tassorelli C20, 21
  69. Tessitore A41
  70. Togha M52, 53
  71. Vaghi G20, 21
  72. Wang SJ54, 55
  73. Ashina M4, 18
  74. Sacco S1
Show Affiliations
Authors Affiliations
  1. 1. Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy
  2. 2. Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy
  3. 3. Hull University Teaching Hospitals NHS Trust., Hull, United Kingdom
  4. 4. Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
  5. 5. Headache Clinic - IRCCS NEUROMED, Pozzilli, IS, Italy
  6. 6. Department of Neurology and Department of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, United States
  7. 7. Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
  8. 8. Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology -Headache Center and Drug Abuse - Laboratory of Clinical Pharmacology and Pharmacogenomics, Modena, Italy
  9. 9. Department of Medicine and Surgery, University of Perugia, Perugia, Italy
  10. 10. Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Italy
  11. 11. Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
  12. 12. Dipartimento di Neuroscienze, Universita Cattolica del Sacro Cuore, Rome, Italy
  13. 13. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino - ICOT - Latina, Italy
  14. 14. IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma Cefalee e Algie Facciali, Bologna, Italy
  15. 15. Department of Neurology, Alfred Health, Melbourne, VIC, Australia
  16. 16. Department of Neurology, Mayo Clinic, Rochester, MN, United States
  17. 17. Department of Health Sciences - Section of Clinical Pharmacology and Oncology - Headache Center, Careggi University Hospital - University of Florence, Italy
  18. 18. Department of Neurology, Severance Hospital, Yonsei University, South Korea
  19. 19. Headache Clinic, Neurology Department, Fleni, Buenos Aires, Argentina
  20. 20. Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
  21. 21. Headache Science and Neurorehabilitation Unit, IRCSS Mondino Foundation, Pavia, Italy
  22. 22. DiBrain Department, Neurophysiopathology Unit, Bari Aldo Moro University, Bari, Italy
  23. 23. Department of Neuroepidemiology, Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), Faculty of Medicine, University Duisburg-Essen, Essen, Germany
  24. 24. Istanbul Faculty of Medicine, Department of Neurology, Istanbul University, Istanbul, Turkey
  25. 25. Headache Center, Amaducci Neurological Clinic, Italy
  26. 26. Department of Neurology-Headache Division, University of Miami, Miller School of Medicine, Miami, United States
  27. 27. Department of Molecular Pathobiology and Pain Research Center, College of Dentistry, New York University, NY, United States
  28. 28. Clinical Unit of Neurology, Headache Center, Department of Medical, Surgical and Health Sciences, University Hospital and Health Services of Trieste, University of Trieste, Trieste, Italy
  29. 29. Unit of Neurosciences, Department of Medicine and Surgery, University of Parma, Parma, Italy
  30. 30. Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea
  31. 31. Department of Neurology, Kasr Al Ainy Hospitals, Faculty of Medicine, Cairo University, Egypt
  32. 32. Dokkyo Medical University, Japan
  33. 33. Pain and Regeneration Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom
  34. 34. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany
  35. 35. Department of Neurology, Beni-Suef University, Egypt
  36. 36. Royal North Shore Hospital, Sydney, Australia
  37. 37. Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester
  38. 38. Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK
  39. 39. Headache Center, University of California, San Francisco, CA, United States
  40. 40. Headache Centre, Neurology - Euganea, Health Unit, Padua, Italy
  41. 41. Headache Centre of Department of Advanced Medical and Surgical Sciences University of Campania Luigi Vanvitelli Naples, Italy
  42. 42. Department of Neurology, Mersin University Medical School, Mersin, Turkey
  43. 43. Brain Research Center, National Yang Ming Chiao Tung University
  44. 44. Department of Neurology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
  45. 45. Hospital das Clinicas da Universidade de Sao Paulo, Sao Paulo, Brazil
  46. 46. Headache Clinic, Neurology Department, Vall d'Hebron Hospital, Barcelona, Spain
  47. 47. Headache and Neurological Pain Research Group, VHIR, Department of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain
  48. 48. Headache Center, Department of Neuroscience Rita Levi Montalcini, University of Torino, Torino, Italy
  49. 49. Ukraine
  50. 50. Department of Neurology, Mayo Clinic, Phoenix, AZ, United States
  51. 51. Department of Neurology, Irmandade Santa Casa de Misericordia de Sao Paulo, Brazil
  52. 52. Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  53. 53. Headache Department, Neurology Ward, Sina Hospital, Medical School, Tehran University of Medical Sciences, Tehran, Iran
  54. 54. Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan
  55. 55. College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

Source: Cephalalgia : an international journal of headache Published:2025


Abstract

We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, actionable recommendations to healthcare professionals. They incorporate evidence-based recommendations from randomized controlled trials and expert-based opinions. The guidelines follow the Grading of Recommendations, Assessment, Development and Evaluation approach for assessing the quality of evidence. The guideline development involved a systematic review of literature across multiple databases, adherence to Cochrane review methods, and a structured framework for data extraction and interpretation. Although the guidelines provide a robust foundation for migraine treatment, they also highlight gaps in current research, such as the paucity of head-to-head drug comparisons and the need for long-term outcome studies. These guidelines serve as a resource to standardize migraine treatment and promote high-quality care across different healthcare settings.