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Determination of Sero-Epidemiological of Htlv-1 and Htlv-2 Among Blood Donors in Guilan Province of Iran



Hashemzadeh MS1 ; Tabalvandani AN2 ; Padasht N4 ; Ayoubi S3 ; Ramzanian R4 ; Hoseinzadeh M4 ; Latifi Z4 ; Tat M1 ; Sharti M1 ; Habibpour M4 ; Arshad S4 ; Dorostkar R1
Authors
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Authors Affiliations
  1. 1. Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biology, Faculty of Science, University of Urmia, Urmia, Iran
  3. 3. Allergy and Asthma Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Microbiology, Faculty of Basic Sciences, Lahijan Branch, Islamic Azad University (IAU), Lahijan, Iran

Source: Journal of Pure and Applied Microbiology Published:2016

Abstract

The unknown cases of serological diagnosis of HTLV-1, 2 virus are of the issues in blood transfusion centers. So in this study, we investigated and determined the seroepidemiological prevalence of HTLV-1 and HTLV-2 among blood donors in Guilan province of Iran. In this experimental study, 200 serum samples of blood donors were evaluated in terms of HTLV-1, 2 viruses by ELISA screening. Repeatability of positive cases was confirmed using Western blot analysis. In Western blot analysis, the number of 50 persons of the donors was reported as negative and there were significant differences between donors with negative and positive results in terms of age and sex. Uncertain cases in the serology of HTLV infection are of the problems of blood transfusion centers around the world. The prevalence of unknown cases among blood donors in Guilan province of Iran was determined more than non-endemic areas and lower than endemic regions.
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