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The Impact of Age-Related Sub-Chronic Exposure to Chlorpyrifos on Metabolic Indexes in Male Rats Publisher Pubmed



Samarghandian S1 ; Foadoddin M2 ; Zardast M2 ; Mehrpour O3, 4 ; Sadighara P5 ; Roshanravan B6 ; Farkhondeh T2
Authors
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Authors Affiliations
  1. 1. Healthy Ageing Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran
  2. 2. Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
  3. 3. Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran
  4. 4. Rocky Mountain Poison and Drug Safety, Denver Health, Denver, CO, United States
  5. 5. Department of Environmental Health Engineering, Food Safety Division, School of Public Health and Center for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran

Source: Environmental Science and Pollution Research Published:2020


Abstract

Chlorpyrifos (CPF), an organophosphorus pesticide (OP), has been implicated in metabolic diseases; however, the data are controversial. Rising age has been found as a main risk factor for metabolic diseases, and it has been proposed that advanced age increases susceptibility to the toxic effects of OPs. Therefore, this investigation aimed to evaluate the impact of CPF on hyperglycemia, hypercholesterolemia, and inflammation in animals with different ages. CPF (5 mg/kg) for 45 consecutive days was administered orally to male Wistar rats with different ages including 2-, 10-, and 20-month-old. The results indicated an increase in glucose and inflammatory indices, and also lipid profile was changed in the serum of aged animals in comparison with the 2-month-old animals. CPF administration amplified these parameters in the 20-month-old rats in comparison with that of aged-matched controls. The histopathological examination also indicated that CPF caused slight to moderate changes in the liver of 2-, 10-, and 20-month-old animals. Cholestasis was also observed in the CPF-administrated 20-month-old rats. In conclusion, aging may increase the susceptibility to CPF-induced metabolic disturbances in the animal models. It is proposed that advancing in age elevates the susceptibility to the metabolic effects of CPF. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
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