Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Assessment of the Risk Factors Associated With Multidrug-Resistant Tuberculosis in Sudan: A Case-Control Study Publisher Pubmed



Elduma AH1 ; Mansournia MA2 ; Foroushani AR2 ; Ali HMH3 ; Elegail AMAS4 ; Elsony A5 ; Holakouienaieni K2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences-International Campus, Tehran, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Multidrug-Resistant Tuberculosis Unit, Communicable and Non-Communicable Diseases Control Directorate, Ministry of Health, Khartoum, Sudan
  4. 4. National Tuberculosis Reference Laboratory, National Public Health Laboratory, Ministry of Health, Khartoum, Sudan
  5. 5. The Epidemiological Laboratory (Epi-Lab), Khartoum, Sudan

Source: Epidemiology and Health Published:2019


Abstract

OBJECTIVES: The emergence of multidrug-resistant tuberculosis (MDR-TB) is a major challenge for the global control of tuberculosis (TB). The aim of this study was to determine the risk factors associated with MDR-TB in Sudan. METHODS: This case-control study was conducted from May 2017 to February 2019. Patients newly diagnosed with MDR-TB were selected as cases, and controls were selected from TB patients who responded to first-line anti-TB drugs. A questionnaire was designed and used to collect data from study participants. Logistic regression was used to evaluate associations between risk factors and MDR-TB infection. The best multivariate model was selected based on the likelihood ratio test. RESULTS: A total of 430 cases and 860 controls were selected for this study. A history of previous TB treatment (adjusted odds ratio [aOR], 54.85; 95% confidence interval [CI], 30.48 to 98.69) was strongly associated with MDR-TB infection. We identified interruption of TB treatment (aOR, 7.62; 95% CI, 3.16 to 18.34), contact with MDR-TB patients (aOR, 5.40; 95% CI, 2.69 to 10.74), lower body weight (aOR, 0.89; 95% CI, 0.87 to 0.91), and water pipe smoking (aOR, 3.23; 95% CI, 1.73 to 6.04) as factors associated with MDR-TB infection. CONCLUSIONS: Previous TB treatment and interruption of TB treatment were found to be the main predictors of MDR-TB. Additionally, this study found that contact with MDR-TB patients and water pipe smoking were associated with MDR-TB infection in Sudan. More efforts are required to decrease the rate of treatment interruption, to strengthen patients' adherence to treatment, and to reduce contact with MDR-TB patients. © 2019 Epidemiology and Health.
Related Docs
1. Resistance of Mycobacterium Tuberculosis Strains to Rifampicin: A Systematic Review and Meta-Analysis, Heliyon (2019)
2. Effects of Sociodemographic Characteristics and Patients' Health Beliefs on Tuberculosis Treatment Adherence in Ethiopia: A Structural Equation Modelling Approach, Infectious Diseases of Poverty (2017)
3. The Targeted Maximum Likelihood Estimation to Estimate the Causal Effects of the Previous Tuberculosis Treatment in Multidrug-Resistant Tuberculosis in Sudan, PLoS ONE (2023)
4. Mycobacterium Tuberculosis Complex Drug Resistance in a High Tuberculosis Incidence Area From the Who Eastern Mediterranean Region, Journal of Pharmacy and Pharmaceutical Sciences (2017)
5. Psychological and Educational Intervention to Improve Tuberculosis Treatment Adherence in Ethiopia Based on Health Belief Model: A Cluster Randomized Control Trial, PLoS ONE (2016)
6. Prevalence of and Risk Factors for Multidrug-Resistant Tuberculosis in Iran and Its Neighboring Countries: Systematic Review and Meta-Analysis, Revista da Sociedade Brasileira de Medicina Tropical (2017)
Experts (# of related papers)
View all Related Experts
Mir Saeed Yekaninejad (2)
Masoumeh Douraghi (1)