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Impact of Curcumin on Traumatic Brain Injury and Involved Molecular Signaling Pathways Publisher Pubmed



Farkhondeh T1 ; Samarghandian S2, 3 ; Roshanravan B4 ; Peivastehroudsari L5, 6
Authors
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Authors Affiliations
  1. 1. Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
  2. 2. Noncommunicable Disease Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran
  3. 3. Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran
  4. 4. Birjand University of Medical Sciences, Birjand, Iran
  5. 5. Devision of Food Safety and Hygiene, Department of Environmental Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Recent Patents on Food# Nutrition and Agriculture Published:2020


Abstract

Traumatic Brain Injury (TBI) is one of the main causes of mortality and morbidity worldwide with no suitable treatment. The present study was designed to review the present literature about the protective effects of curcumin and the underlying mechanism against TBI. All published English language papers from beginning to 2019 were selected in this study. The findings indicate that curcumin may be effective against TBI outcomes by modulating the molecular signaling pathways involved in oxidative stress, inflammation, apoptosis, and autophagy. However, more experimental studies should be done to identify all mechanisms involved in the pathogenesis of TBI. Patents for Curcumin and chronic inflammation and traumatic brain injury management (WO2017097805A1 and US9101580B2) were published. In conclusion, the present study confirmed the potential therapeutic impact of curcumin for treating TBI. © 2020 Bentham Science Publishers.
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