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Immunomodulatory Characteristics of Mesenchymal Stem Cells and Their Role in the Treatment of Multiple Sclerosis Publisher Pubmed



Gharibi T1, 2 ; Ahmadi M1, 2 ; Seyfizadeh N1, 2 ; Jadidiniaragh F3 ; Yousefi M1, 2
Authors
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Authors Affiliations
  1. 1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Cellular Immunology Published:2015


Abstract

Multiple Sclerosis (MS) is a chronic inflammatory neurodegenerative disease of central nervous system (CNS). Although the main cause of MS is not clear, studies suggest that MS is an autoimmune disease which attacks myelin sheath of neurons. There are different therapeutic regimens for MS patients including interferon (IFN)-β, glatiramer acetate (GA), and natalizumab. However, such therapies are not quite effective and are associated with some side effects. So which, there is no complete therapeutic method for MS patients. Regarding the potent immunomodulatory effects of mesenchymal stem cells (MSCs) and their ameliorative effects in experimental autoimmune encephalopathy (EAE), it seems that MSCs may be a new therapeutic method in MS therapy. MSC transplantation is an approach to regulate the immune system in the region of CNS lesions. In this review, we have tried to discuss about the immunomodulatory properties of MSCs and their therapeutic mechanisms in MS patients. © 2015 Elsevier Inc.
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