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The Role of Nk Cells and Their Exosomes in Graft Versus Host Disease and Graft Versus Leukemia Publisher Pubmed



Zafarani A1 ; Taghavifarahabadi M2 ; Razizadeh MH3 ; Amirzargar MR1 ; Mansouri M4 ; Mahmoudi M5
Authors
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Authors Affiliations
  1. 1. Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Stem Cell Reviews and Reports Published:2023


Abstract

Natural killer (NK) cells are one of the innate immune cells that play an important role in preventing and controlling tumors and viral diseases, but their role in hematopoietic stem cell transplantation (HCT) is not yet fully understood. However, according to some research, these cells can prevent infections and tumor relapse without causing graft versus host disease (GVHD). In addition to NK cells, several studies are about the anti-leukemia effects of NK cell-derived exosomes that can highlight their roles in graft-versus-leukemia (GVL). In this paper, we intend to investigate the results of various articles on the role of NK cells in allogeneic hematopoietic cell transplantation and also their exosomes in GVL. Also, we have discussed the antiviral effects of these cells in post-HCT cytomegalovirus infection. Graphical Abstract: [Figure not available: see fulltext.]. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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