Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Role of Nitric Oxide–Cgmp Pathway in Selegiline Antidepressant-Like Effect in the Mice Forced Swim Test Publisher Pubmed



Ostadhadi S1, 2, 4 ; Shakiba S1, 2, 4 ; Norouzijavidan A1 ; Nikoui V3 ; Zolfaghari S5 ; Chamanara M2 ; Dehpour AR1, 2, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Pharmacological Reports Published:2018


Abstract

Background: Considering the pivotal role of nitric oxide (NO) pathway in depressive disorders, the aim of the present study was to investigate the antidepressant-like effect of selegiline in mice forced swimming test (FST), and possible involvement of NO-cyclic guanosine monophosphate (cGMP) pathway in this action. Methods: After assessment of locomotor activity in open-field test, mice were forced to swim individually and the immobility time of the last 4 min was evaluated. All drugs were given intraperitoneally (ip). Results: Selegiline (10 mg/kg) decreased the immobility time in the FST similar to fluoxetine (20 mg/kg). Pretreatment with L-arginine (NO precursor, 750 mg/kg) or sildenafil (a phosphodiesterase 5 inhibitor, 5 mg/kg) significantly reversed the selegiline anti-immobility effect. Sub-effective dose of selegiline (1 mg/kg) showed a synergistic antidepressant effect with NG-nitro-L-arginine methyl ester (L-NAME, inhibitor of NO synthase, 10 mg/kg) or 7-nitroindazole (specific neuronal NO synthase inhibitor, 30 mg/kg), but not with aminoguanidine (specific inducible NO synthase inhibitor, 50 mg/kg). Pretreatment of mice with methylene blue (an inhibitor of NO synthase and soluble guanylyl cyclase, 10 mg/kg) significantly produced a synergistic response with the sub-effective dose of selegiline. Neither of the drugs changed the locomotor activity. Also, hippocampal and prefrontal cortex (PFC) nitrite content was significantly lower in selegiline-injected mice compared to saline-administrated mice. Also, co-injection of 7-nitroindazole with selegiline produced a significant reduction in hippocampal or PFC nitrite contents. Conclusions: It is concluded that selegiline possesses antidepressant-like effect in mice FST through inhibition of L-arginine-NO-cyclic guanosine monophosphate pathway. © 2018 Institute of Pharmacology, Polish Academy of Sciences
Related Docs
View other Related Docs
1. The Role of Nmda Receptor and Nitric Oxide/Cyclic Guanosine Monophosphate Pathway in the Antidepressant-Like Effect of Dextromethorphan in Mice Forced Swimming Test and Tail Suspension Test, Biomedicine and Pharmacotherapy (2017)
2. Antidepressant Effect of Pramipexole in Mice Forced Swimming Test: A Cross Talk Between Dopamine Receptor and Nmda/Nitric Oxide/Cgmp Pathway, Biomedicine and Pharmacotherapy (2016)
3. Antidepressant-Like Effect of Ethanol in Mice Forced Swimming Test Is Mediated Via Inhibition of Nmda/Nitric Oxide/Cgmp Signaling Pathway, Alcohol (2021)
4. Pharmacological Profile for the Contribution of No/Cgmp Pathway on Chlorpheniramine Antidepressant-Like Effect in Mice Forced Swim Test, Acta Medica Iranica (2018)
5. Nitric Oxide Involvement in Additive Antidepressant-Like Effect of Agmatine and Lithium in Mice Forced Swim Test, Psychiatry Research (2018)
6. Pharmacological Evidence for the Involvement of the Nmda Receptor and Nitric Oxide Pathway in the Antidepressant-Like Effect of Lamotrigine in the Mouse Forced Swimming Test, Biomedicine and Pharmacotherapy (2016)
7. Involvement of Nmda Receptors and L-Arginine/Nitric Oxide/Cyclic Guanosine Monophosphate Pathway in the Antidepressant-Like Effects of Topiramate in Mice Forced Swimming Test, Brain Research Bulletin (2016)
8. Involvement of Nitric Oxide-Cyclic Guanosine Monophosphate Pathway in the Antidepressant-Like Effect of Tropisetron and Ondansetron in Mice Forced Swimming Test and Tail Suspension Test, European Journal of Pharmacology (2016)
Experts (# of related papers)
View all Related Experts
Ahmad Reza Dehpour (63)
Raziyeh Mohammad Jafari (3)
Other Related Docs
9. Agmatine Enhances the Antidepressant-Like Effect of Lithium in Mouse Forced Swimming Test Through Nmda Pathway, Biomedicine and Pharmacotherapy (2017)
10. Involvement of No/Cgmp Pathway in the Antidepressant-Like Effect of Gabapentin in Mouse Forced Swimming Test, Naunyn-Schmiedeberg's Archives of Pharmacology (2016)
11. Lithium Attenuated the Behavioral Despair Induced by Acute Neurogenic Stress Through Blockade of Opioid Receptors in Mice, Biomedicine and Pharmacotherapy (2016)
12. Elevated Level of Nitric Oxide Mediates the Anti-Depressant Effect of Rubidium Chloride in Mice, European Journal of Pharmacology (2015)
13. Evaluation of the Pharmacological Involvement of Atp-Sensitive Potassium (Katp) Channels in the Antidepressant-Like Effects of Topiramate on Mice, Naunyn-Schmiedeberg's Archives of Pharmacology (2019)
14. Minocycline Attenuates Depressive-Like Behaviour Induced by Rat Model of Testicular Torsion: Involvement of Nitric Oxide Pathway, Basic and Clinical Pharmacology and Toxicology (2016)
15. Possible Involvement of Atp-Sensitive Potassium Channels in the Antidepressant-Like Effects of Gabapentin in Mouse Forced Swimming Test, Canadian Journal of Physiology and Pharmacology (2017)
16. Possible Involvement of Atp-Sensitive Potassium Channels in the Antidepressant-Like Effect of Baclofen in Mouse Forced Swimming Test, Pharmacological Reports (2016)
17. The Effect of Nitrazepam on Depression and Curiosity in Behavioral Tests in Mice: The Role of Potassium Channels, European Journal of Pharmacology (2016)
18. On the Effect of Minocycline on the Depressive-Like Behavior of Mice Repeatedly Exposed to Malathion: Interaction Between Nitric Oxide and Cholinergic System, Metabolic Brain Disease (2016)
19. Involvement of No/Nmda-R Pathway in the Behavioral Despair Induced by Amphetamine Withdrawal, Brain Research Bulletin (2018)
20. The Involvement of Nmda Receptor/No/Cgmp Pathway in the Antidepressant Like Effects of Baclofen in Mouse Force Swimming Test, Neuroscience Letters (2016)
21. Anticonvulsant Effect of Dextrometrophan on Pentylenetetrazole-Induced Seizures in Mice: Involvement of Nitric Oxide and N-Methyl-D-Aspartate Receptors, Epilepsy and Behavior (2016)
22. Involvement of Nmda Receptors in the Antidepressant-Like Effect of Tramadol in the Mouse Forced Swimming Test, Brain Research Bulletin (2017)
23. Co-Administration of the Low Dose of Orexin and Nitrergic Antagonists Induces an Antidepressant-Like Effect in Mice, Biomedicine and Pharmacotherapy (2019)
24. Evidence for the Involvement of Nitric Oxide in Cholestasis-Induced Itch Associated Response in Mice, Biomedicine and Pharmacotherapy (2016)
25. Mammalian Target of Rapamycin (Mtor)/Nitric Oxide System Possibly Modulate Antidepressant-Like Effect of 17Α-Ethinyl Estradiol in Ovariectomized Mice, Biomedicine and Pharmacotherapy (2017)
26. Development of Resistance to Serotonin-Induced Itch in Bile Duct Ligated Mice, Clinical and Experimental Pharmacology and Physiology (2017)
27. Involvement of N-Methyl-D-Aspartate Receptors in the Antidepressant-Like Effect of 5-Hydroxytryptamine 3 Antagonists in Mouse Forced Swimming Test and Tail Suspension Test, Pharmacology Biochemistry and Behavior (2016)
28. Possible Involvement of Nitric Oxide in Antidepressant-Like Effect of Silymarin in Male Mice, Pharmaceutical Biology (2015)
29. Co-Occurrence of Anxiety and Depressive-Like Behaviors Following Adolescent Social Isolation in Male Mice; Possible Role of Nitrergic System, Physiology and Behavior (2015)
30. 17Α-Ethinyl Estradiol Attenuates Depressive-Like Behavior Through Gabaa Receptor Activation/Nitrergic Pathway Blockade in Ovariectomized Mice, Psychopharmacology (2016)
31. Neurobiology and Consequences of Social Isolation Stress in Animal Model—A Comprehensive Review, Biomedicine and Pharmacotherapy (2018)
32. Melatonin Attenuated the Behavioral Despair Induced by Acute Neurogenic Stress Through Blockade of N-Methyl D-Aspartate Receptors in Mice, Heliyon (2021)
33. Neurophysiologic Implications of Neuronal Nitric Oxide Synthase, Reviews in the Neurosciences (2020)
34. The Role of Opioid and Nitrergic Systems in Dual Modulation of Seizure Susceptibility, Advancements in Life Sciences (2020)
35. Anticonvulsant Effect of Minocycline on Pentylenetetrazole-Induced Seizure in Mice: Involvement of Nitric Oxide and N-Methyl-D-Aspartate Receptor, Canadian Journal of Physiology and Pharmacology (2018)
36. Fluoxetine Reverses the Behavioral Despair Induced by Neurogenic Stress in Mice: Role of N-Methyl-D-Aspartate and Opioid Receptors, Canadian Journal of Physiology and Pharmacology (2016)
37. Involvement of Opioid System in Antidepressant-Like Effect of the Cannabinoid Cb1 Receptor Inverse Agonist Am-251 After Physical Stress in Mice, Clinical and Experimental Pharmacology and Physiology (2016)
38. Activation of Cannabinoid Receptors Elicits Antidepressant-Like Effects in a Mouse Model of Social Isolation Stress, Brain Research Bulletin (2017)
39. Behavioral Despair Associated With a Mouse Model of Crohn's Disease: Role of Nitric Oxide Pathway, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2016)
40. Lithium Attenuated the Depressant and Anxiogenic Effect of Juvenile Social Stress Through Mitigating the Negative Impact of Interlukin-1Β and Nitric Oxide on Hypothalamic-Pituitary-Adrenal Axis Function, Neuroscience (2016)
41. Evidence for the Involvement of Nmda Receptors in the Antidepressant-Like Effect of Nicotine in Mouse Forced Swimming and Tail Suspension Tests, Psychopharmacology (2015)
42. Pharmacological Evidence for the Involvement of Adenosine Triphosphate Sensitive Potassium Channels in Chloroquine-Induced Itch in Mice, Pharmacological Reports (2017)
43. Effect of Withania Somnifera Dunal Root Extract on Behavioral Despair Model in Mice: A Possible Role for Nitric Oxide, Acta Medica Iranica (2016)
44. Involvement of Opioid System in Behavioral Despair Induced by Social Isolation Stress in Mice, Biomedicine and Pharmacotherapy (2019)
45. Effects of Short Term and Long Term Extremely Low Frequency Magnetic Field on Depressive Disorder in Mice: Involvement of Nitric Oxide Pathway, Life Sciences (2016)
46. Methadone's Effects on Pentylenetetrazole-Induced Seizure Threshold in Mice: Nmda/Opioid Receptors and Nitric Oxide Signaling, Annals of the New York Academy of Sciences (2019)
47. Pharmacological Evidence of Involvement of Nitric Oxide Pathway in Anti-Pruritic Effects of Sumatriptan in Chloroquine-Induced Scratching in Mice, Fundamental and Clinical Pharmacology (2018)
48. Involvement of the Monoaminergic System in the Antidepressant-Like Effect of the Crude Extract of Mentha Piperita (Lamiaceae) in the Forced Swimming Test in Mice, Synergy (2017)
49. Streptozotocin Induced Oxidative Stress, Innate Immune System Responses and Behavioral Abnormalities in Male Mice, Neuroscience (2017)
50. Lithium Attenuates the Proconvulsant Effect of Adolescent Social Isolation Stress Via Involvement of the Nitrergic System, Epilepsy and Behavior (2016)