Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Optimised Gelma/Tragacanth Gum Hydrogel Loaded With Vanillic Acid for Biomedical Applications Publisher Pubmed



A Golshirazi ATEFEH ; S Labbaf SHEYDA ; J Varshosaz JALEH
Authors

Source: International Journal of Biological Macromolecules Published:2025


Abstract

In this study a hybrid hydrogel based on GelMA incorporated with Tragacanth gum that can improve compressive properties and swelling of the GelMA and provide a sustained release of vanillic acid is developed and thoroughly evaluated. This hydrogel hybrid system undergoes gelation through UV crosslinking. The presence of Tragacanth was found to increase the swelling of the hydrogel system from 500 to 1200 times and the compressive strength from 15 ± 1 kPa to 49 ± 3 kPa. Also, rheological and injectability investigations confirmed that the proposed hydrogel system is suitable for use as an injectable hydrogel. In addition, the drug loading and release profile of vanillic acid, used as a model drug, was investigated. The results revealed sustained release behavior that follows the Korsmeyer-Peppas model and non-Fickian diffusion mechanism. The results demonstrate the synergistic effects of the GelMA/Tragacanth gum hybrid system, highlighting the potential of this degradable and non-toxic composite hydrogel for advanced biomedical applications such as controlled drug delivery systems and wound healing. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Development and Physical Characterization of a Periodontal Bioadhesive Gel of Metronidazole, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2002)
2. Thermosensitive Hydrogel Containing Sertaconazole Loaded Nanostructured Lipid Carriers for Potential Treatment of Fungal Keratitis, Pharmaceutical Development and Technology (2019)
3. Preparation and Characterization of an Injectable Thermosensitive Hydrogel for Simultaneous Delivery of Paclitaxel and Doxorubicin, Research in Pharmaceutical Sciences (2018)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (6)
Vajihe Akbari (3)
Other Related Docs
4. Gellan Gum–Based Nanocomposite Hydrogels, Application of Gellan Gum as a Biomedical Polymer (2024)
5. Tragacanth Gum-Deep Eutectic Solvent-Based Eutectogels for Dextromethorphan Transdermal Delivery and Induced Rheumatoid Arthritis Treatment in Rat, International Journal of Biological Macromolecules (2025)
6. A Brief Review of Hydrogels for Drug Delivery for Different Organs of the Body: Synthesis, Categorization, and Organ-Specific Applications, Nanochemistry Research (2024)
7. Injectable Gellan Gum/Lignocellulose Nanofibrils Hydrogels Enriched With Melatonin Loaded Forsterite Nanoparticles for Cartilage Tissue Engineering: Fabrication, Characterization and Cell Culture Studies, Materials Science and Engineering C (2020)
8. Polysaccharides Derived From Tragacanth As Biocompatible Polymers and Gels, Journal of Applied Polymer Science (2013)
9. An Injectable Carboxymethyl Chitosan-Methylcellulose-Pluronic Hydrogel for the Encapsulation of Meloxicam Loaded Nanoparticles, International Journal of Biological Macromolecules (2020)
10. A Robust Emulsion Gel Based on Κ-Carrageenan and Dialdehyde Starch for Stimuli-Responsive of Hydrophobic Bioactive Agents, International Journal of Biological Macromolecules (2025)
11. Ultrahigh-Water-Content Biocompatible Gelatin-Based Hydrogels: Toughened Through Micro-Sized Dissipative Morphology As an Effective Strategy, Materials Science and Engineering C (2021)
12. Self-Healing Hydrogels From Hyaluronic Acid and Dialdehyde Carboxymethyl Cellulose for Accelerated Wound Healing, Journal of Colloid and Interface Science (2025)
13. Comparison the Effects of Chitosan and Hyaluronic Acid-Based Thermally Sensitive Hydrogels Containing Rosuvastatin on Human Osteoblast-Like Mg-63 Cells, Research in Pharmaceutical Sciences (2020)
14. Double-Walled Microspheres Loaded With Meglumine Antimoniate: Preparation, Characterization and in Vitro Release Study, Drug Development and Industrial Pharmacy (2014)
15. Novel Multi-Layer Silica Aerogel/Pva Composite for Controlled Drug Delivery, Materials Research Express (2019)
16. Thermo-Responsive Hydrogels Based on Methylcellulose/Persian Gum Loaded With Taxifolin Enhance Bone Regeneration: An in Vitro/In Vivo Study, Cellulose (2022)
17. Dentin Extracellular Matrix Loaded Bioactive Glass/Gelma Support Rapid Bone Mineralization for Potential Pulp Regeneration, International Journal of Biological Macromolecules (2023)
18. Acceleration of Wound Healing in Rats by Modified Lignocellulose Based Sponge Containing Pentoxifylline Loaded Lecithin/Chitosan Nanoparticles, Gels (2022)
19. Proanthocyanidin As a Crosslinking Agent for Fibrin, Collagen Hydrogels and Their Composites With Decellularized Wharton’S-Jelly-Extract for Tissue Engineering Applications, Journal of Bioactive and Compatible Polymers (2020)
20. Hydrogels and Biohydrogels: Investigation of Origin of Production, Production Methods, and Application, Polymer Bulletin (2023)