Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Baghdadite/Polycaprolactone Nanocomposite Scaffolds: Preparation, Characterisation, and in Vitro Biological Responses of Human Osteoblast-Like Cells (Saos-2 Cell Line) Publisher



Arefpour A1 ; Kasiriasgarani M1 ; Monshi A2 ; Karbasi S3 ; Doostmohammadi A4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Najafabad Branch, Islamic Azad University, Advanced Materials Research Center, Department of Materials Engineering, Najafabad, Iran
  2. 2. Isfahan University of Technology, Department of Materials Engineering, Isfahan, Iran
  3. 3. Isfahan University of Medical Sciences, School of Advanced Technology in Medicine, Isfahan, Iran
  4. 4. York University, Department of Mechanical Engineering, Lassonde School of Engineering, Toronto, Canada

Source: Materials Technology Published:2020


Abstract

In the present research, porous composite scaffolds consisting of baghdadite scaffolds with polycaprolactone (PCL) coating, were fabricated via combining polyurethane sponge replication method and dip-coating processes and characterised by x-ray diffraction (XRD), scanning electron microscope (SEM), and porosity and compressive strength measurements. MTT assay and cell attachment were carried out via human osteoblast-like cell culture on the scaffolds. Results showed that the scaffolds possessed porous structures with porosity about 70-83%, and compressive strengths 0.18–1.31 MPa. Polycaprolactone can affect a significant role in improving the mechanical properties of baghdadite scaffold. It could enhance the compressive strength of baghdadite scaffold from 0.18 to 0.41 MPa while its porous structure is maintained. The evaluation of cell viability and attachment, verified no cytotoxicity, and good attachment and proliferation of cells on the scaffolds. To summarise, baghdadite–PCL composite scaffold with a porous structure, great mechanical properties and excellent biological responses is a promising candidate for bone tissue engineering. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. In Vitro Bioactivity of Baghdadite-Coated Pcl –Graphene Nanocomposite Scaffolds: Mechanism of Baghdadite and Apatite Formation, Materials Technology (2020)
2. Mechanical Behaviour, Hybridisation and Osteoblast Activities of Novel Baghdadite/ Pcl-Graphene Nanocomposite Scaffold: Viability, Cytotoxicity and Calcium Activity, Materials Technology (2022)
3. Preparation of a Novel Biodegradable Nanocomposite Scaffold Based on Poly (3-Hydroxybutyrate)/Bioglass Nanoparticles for Bone Tissue Engineering, Journal of Materials Science: Materials in Medicine (2010)
4. Evaluation of Physical, Mechanical and Biological Properties of Bioglass/Titania Scaffold Coated With Poly (3-Hydroxybutyrate)-Chitosan for Bone Tissue Engineering Applications, Materials Technology (2020)
5. Incorporation of Inorganic Bioceramics Into Electrospun Scaffolds for Tissue Engineering Applications: A Review, Ceramics International (2022)
6. Keratin-Containing Scaffolds for Tissue Engineering Applications: A Review, Journal of Biomaterials Science, Polymer Edition (2024)
7. Modified Poly(3-Hydroxybutyrate)-Based Scaffolds in Tissue Engineering Applications: A Review, International Journal of Biological Macromolecules (2021)
8. Evaluation of Physical and Mechanical Properties of Fi-Tri-Calcium Phosphate/Poly-3-Hydroxybutyrate Nanocomposite Scaffold for Bone Tissue Engineering Application, Scientia Iranica (2017)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (80)
Mohammad Rafienia (51)
Other Related Docs
9. Synthesis and Characterization of Bioactive Glass Coated Forsterite Scaffold for Tissue Engineering Applications, Journal of Alloys and Compounds (2017)
10. Evaluation of Mechanical Property and Bioactivity of Nano-Bioglass 45S5 Scaffold Coated With Poly-3-Hydroxybutyrate, Journal of Materials Science: Materials in Medicine (2015)
11. Bioceramic Calcium Phosphate-Polymer Scaffolds: A Promising Strategy for Osteochondral Repair and Regenerative Medicine, Materials Chemistry and Physics (2023)
12. Mechanical and Cytotoxicity Evaluation of Nanostructured Hydroxyapatite-Bredigite Scaffolds for Bone Regeneration, Materials Science and Engineering C (2016)
13. Evaluation of Physical, Mechanical and Biological Properties of Β-Tri-Calcium Phosphate/Poly-3-Hydroxybutyrate Nano Composite Scaffold for Bone Tissue Engineering Application, Materials Technology (2021)
14. Evaluation of the Effects of Nano-Tio2 on Bioactivity and Mechanical Properties of Nano Bioglass-P3hb Composite Scaffold for Bone Tissue Engineering, Journal of Materials Science: Materials in Medicine (2016)
15. Effects of Bioglass Nanoparticles on Bioactivity and Mechanical Property of Poly(3-Hydroxybutirate) Scaffolds, Scientia Iranica (2013)
16. The Influence of Bioglass Nanoparticles on the Biodegradation and Biocompatibility of Poly (3-Hydroxybutyrate) Scaffolds, International Journal of Artificial Organs (2012)
17. Mechanical Evaluation of Nhap Scaffold Coated With Poly-3-Hydroxybutyrate for Bone Tissue Engineering, Journal of Nanoscience and Nanotechnology (2013)
18. Fabrication and Characterization of Hydroxyapatite-Coated Forsterite Scaffold for Tissue Regeneration Applications, Bulletin of Materials Science (2015)
19. A Ternary Nanocomposite Fibrous Scaffold Composed of Poly(Ε-Caprolactone)/Gelatin/Gehlenite (Ca2al2sio7): Physical, Chemical, and Biological Properties in Vitro, Polymers for Advanced Technologies (2021)
20. Physical and Mechanical Properties of a Poly-3-Hydroxybutyratecoated Nanocrystalline Hydroxyapatite Scaffold for Bone Tissue Engineering, Journal of Porous Materials (2012)
21. Incorporation of Nanohydroxyapatite and Vitamin D3 Into Electrospun Pcl/Gelatin Scaffolds: The Influence on the Physical and Chemical Properties and Cell Behavior for Bone Tissue Engineering, Polymers for Advanced Technologies (2018)
22. A 3D Nanostructured Calcium-Aluminum-Silicate Scaffold With Hierarchical Meso-Macroporosity for Bone Tissue Regeneration: Fabrication, Sintering Behavior, Surface Modification and in Vitro Studies, Journal of the European Ceramic Society (2021)
23. Physical, Mechanical and Biological Performance of Phb-Chitosan/Mwcnts Nanocomposite Coating Deposited on Bioglass Based Scaffold: Potential Application in Bone Tissue Engineering, International Journal of Biological Macromolecules (2020)
24. Synergetic Effect of Bioglass and Nano Montmorillonite on 3D Printed Nanocomposite of Polycaprolactone/Gelatin in the Fabrication of Bone Scaffolds, International Journal of Biological Macromolecules (2024)
25. Physical, Mechanical, and Biological Performance of Chitosan-Based Nanocomposite Coating Deposited on the Polycaprolactone-Based 3D Printed Scaffold: Potential Application in Bone Tissue Engineering, International Journal of Biological Macromolecules (2023)
26. Biological Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate) Based Electrospun Nanocomposite Scaffolds for Cartilage Tissue Engineering Application, Materials Technology (2020)
27. Poly (Ε-Caprolactone) Incorporated Bioactive Glass Nanoparticles and Simvastatin Nanocomposite Nanofibers: Preparation, Characterization and in Vitro Drug Release for Bone Regeneration Applications, Chemical Engineering Journal (2013)
28. Natural Hydroxyapatite/Diopside Nanocomposite Scaffold for Bone Tissue Engineering Applications: Physical, Mechanical, Bioactivity and Biodegradation Evaluation, Materials Technology (2022)
29. Fabrication, Characterization and Examination of in Vitro of Baghdadite Nanoparticles for Biomedical Applications, Materials Research Express (2019)
30. Biological Evaluation and Osteogenic Potential of Polyhydroxybutyrate-Keratin/Al2o3 Electrospun Nanocomposite Scaffold: A Novel Bone Regeneration Construct, International Journal of Biological Macromolecules (2023)
31. Incorporation of Multi-Walled Carbon Nanotubes Into Electrospun Pcl/Gelatin Scaffold: The Influence on the Physical, Chemical and Thermal Properties and Cell Response for Tissue Engineering, Materials Technology (2020)
32. Morphology and Degradation of Poly (3-Hydroxybutyrate)/ Nano-Hydroxyapatite Scaffold Used in Tissue Engineering, Journal of Isfahan Medical School (2012)
33. Pcl/Agarose 3D-Printed Scaffold for Tissue Engineering Applications: Fabrication, Characterization, and Cellular Activities, Research in Pharmaceutical Sciences (2023)
34. Effects of Surface Modification on the Mechanical and Structural Properties of Nanofibrous Poly(Ε-Caprolactone)/Forsterite Scaffold for Tissue Engineering Applications, Materials Science and Engineering C (2013)
35. Effect of Cellulose Nanofibers on Polyhydroxybutyrate Electrospun Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2022)
36. Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies, Polymers for Advanced Technologies (2020)
37. Silk Fibroin-Chondroitin Sulfate-Alginate Porous Scaffolds: Structural Properties and in Vitro Studies, Journal of Applied Polymer Science (2014)
38. Evaluation of the Effects of Starch on Polyhydroxybutyrate Electrospun Scaffolds for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2021)
39. Effects of Nano-Bioactive Glass on Structural, Mechanical and Bioactivity Properties of Poly (3-Hydroxybutyrate) Electrospun Scaffold for Bone Tissue Engineering Applications, Materials Technology (2019)
40. Electrospun Polycaprolactone/Gelatin/Bioactive Glass Nanoscaffold for Bone Tissue Engineering, International Journal of Polymeric Materials and Polymeric Biomaterials (2019)
41. 3D Printed Polycaprolactone/Gelatin/Ordered Mesoporous Calcium Magnesium Silicate Nanocomposite Scaffold for Bone Tissue Regeneration, Journal of Materials Science: Materials in Medicine (2024)
42. Fabrication and Characterization of 3D Nanostructured Polycaprolactone-Gelatin/Nanohydroxyapatite-Nanoclay Scaffolds for Bone Tissue Regeneration, Journal of Polymers and the Environment (2024)
43. Effects of Cartilage Acellular Solubilised Ecm on Physicomechanical and Biological Properties of Polycaprolactone/Fibrin Hybrid Scaffold Fabricated by 3D-Printing and Salt-Leaching Methods, Materials Technology (2022)
44. In Vitro Studies of Polycaprolactone Nanofibrous Scaffolds Containing Novel Gehlenite Nanoparticles, Journal of Medical Signals and Sensors (2021)
45. Investigation the Mechanical Properties of a Novel Multicomponent Scaffold Coated With a New Bio-Nanocomposite for Bone Tissue Engineering: Fabrication, Simulation and Characterization, Journal of Materials Research and Technology (2021)
46. Development of Electrospun Poly (Vinyl Alcohol)-Based Bionanocomposite Scaffolds for Bone Tissue Engineering, Journal of Biomedical Materials Research - Part A (2018)
47. Effect of Calcium Silicate Nanoparticle on Surface Feature of Calcium Phosphates Hybrid Bio-Nanocomposite Using for Bone Substitute Application, Powder Technology (2020)
48. Preparation and Characterization of Aligned Porous Pcl/Zein Scaffolds As Drug Delivery Systems Via Improved Unidirectional Freeze-Drying Method, Materials Science and Engineering C (2016)
49. Investigation of the Mechanical Properties of a Bony Scaffold for Comminuted Distal Radial Fractures: Addition of Akermanite Nanoparticles and Using a Freeze-Drying Technique, Journal of the Mechanical Behavior of Biomedical Materials (2021)
50. Tunable Cellular Interactions and Physical Properties of Nanofibrous Pcl-Forsterite: Gelatin Scaffold Through Sequential Electrospinning, Composites Science and Technology (2013)