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Investigating the Effect of Combined Use of Selenium and Myo-Inositol Supplements on Thyroid Function and Autoimmune Characteristics in Thyroid Disorders: A Systematic Review and Meta-Analysis Publisher Pubmed



Yavari M1 ; Akbari M1 ; Ramezani Ahmadi A1 ; Siavash Dastjerdi M2 ; Hashemi MS3
Authors
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Authors Affiliations
  1. 1. Isfahan Endocrine and Metabolism Research Centre (IEMRC), Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Endocrinology & Metabolism, Isfahan Endocrine and Metabolism Research Center (IEMRC), Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Nursing & Midwifery Care Research Center, Department of critical care, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Expert Review of Endocrinology and Metabolism Published:2024


Abstract

Background: This study aimed to systematically review the effect of selenium and inositol combination on thyroid function, autoimmune characteristics in thyroid diseases. Research design and methods: To identify eligible studies, a systematic search was conducted in the PubMed/MEDLINE, Science-Direct, CINHAL, EMBASE, SCOPUS, Psychinfo, Cochrane, ProQuest, and Web of Science were searched using the main concepts, and all English-written articles that were published between 2007 and 2022 and had an available full text were examined. Results: The data analysis of this research revealed that after the simultaneous use of selenium and inositol supplements, the level of Triiodothyronine(T3) increased by 0.105 in patients with thyroid disorders although this increase was not significant (P-value: 0.228). The level of Thyroxine (T4) significantly increased by 0.06 (P-value: 0.04). Anti-Thyroid Peroxidase Antibody (TPOAb) titer decreased by 119.36%, which was not significant (P-value: 0.070). Finally, the level of Thyroid-stimulating hormone (TSH) decreased by 1.45%, which was a significant change (P-value: 0.001). Conclusion: It was observed that simultaneous use of selenium and inositol supplements did not change the T3 and TPOAb titer levels; however, it leads to a decrease in TSH and increase in T4 levels. Further studies are required due to the limited number of studies. © 2023 Informa UK Limited, trading as Taylor & Francis Group.
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