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Immune Checkpoint Inhibitors and Iga Nephropathy; a Rare Side Effect Publisher



Md Mobarakeh Maryam DEHGHANI ; Ar Maghsoudi Ahmad REZA
Authors

Source: Journal of Nephropharmacology Published:2025


Abstract

The pathophysiological mechanisms of secondary IgA nephropathy (IgAN) containing IgA-mediated immune complex deposition in the glomeruli. However, the specific triggers can vary widely, including infections, liver disease, and malignancies, in addition to drug-induced factors. IgAN is a rare however is a serious complication of immune checkpoint inhibitor (ICI) therapy that can lead to acute kidney injury. Clinically, the diagnosis of sIgAN typically follows a temporal association between medication administration and the onset of renal symptoms, such as hematuria or proteinuria. A kidney biopsy is often necessary to confirm the diagnosis and rule out other causes of nephropathy. © 2025 Elsevier B.V., All rights reserved.
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