Atypical Memory B Cells Increase in the Peripheral Blood of Patients With Breast Cancer Regardless of Lymph Node Involvement

Atypical Memory B Cells Increase in the Peripheral Blood of Patients With Breast Cancer Regardless of Lymph Node Involvement Publisher Pubmed

Azizi A¹ ; Mehdipour F² ; Samadi M³ ; Rasolmali R⁴ ; Talei AR⁵ ; Ghaderi A^{2, 6}

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1. Department of Immunology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2. Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4. Department of Pathology, Shiraz Central Hospital, Shiraz, Iran
5. Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
6. Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: BMC Immunology Published:2024

Abstract

Background: Breast cancer is the most common cancer in females. The immune system has a crucial role in the fight against cancer. B and T cells, the two main components of the adaptive immunity, are critical players that specifically target tumor cells. However, B cells, in contrast to T cells, and their role in cancer inhibition or progression is less investigated. Accordingly, in this study, we assessed and compared the frequency of naive and different subsets of memory B cells in the peripheral blood of patients with breast cancer and healthy women. Results: We found no significant differences in the frequencies of peripheral CD19+ B cells between the patients and controls. However, there was a significant decrease in the frequency of CD19+IgM+ B cells in patients compared to the control group (P=0.030). Moreover, the patients exhibited higher percentages of atypical memory B cells (CD19+CD27‒IgM‒, P=0.006) and a non-significant increasing trend in switched memory B cells (CD19+CD27+IgM‒, P=0.074). Further analysis revealed a higher frequency of atypical memory B cells (aMBCs) in the peripheral blood of patients without lymph node involvement as well as those with a tumor size greater than 2cm or with estrogen receptor (ER) negative/progesterone receptor (PR) negative tumors, compared with controls (P=0.030, P=0.040, P=0.031 and P=0.054, respectively). Conclusion: Atypical memory B cells (CD19+CD27‒IgM‒) showed a significant increase in the peripheral blood of patients with breast cancer compared to the control group. This increase seems to be associated with tumor characteristics. Nevertheless, additional research is necessary to determine the precise role of these cells during breast cancer progression © The Author(s) 2024.

2. The Correlation of Cd19 + Cd24 + Cd38 + B Cells and Other Clinicopathological Variables With the Proportion of Circulating Tregs in Breast Cancer Patients, Breast Cancer (2017)

3. Effect of Online Mindfulness-Based Cognitive Therapy on Pain Severity and Life Quality in Women Receiving Treatment for Breast Cancer; [تأثیر آموزش مجازي درمان شناختی مبتنی بر ذهنآگاهی بر شدت درد و کیفیت زندگی زنان تحت درمان سرطان پستا ن], Iranian Journal of Breast Diseases (2025)

4. Assessment of the Expression Level of B-Cell Lymphoma 6 (Bcl6) in Peripheral Blood Cd38+ B Lymphocytes in Patients With Common Variable Immunodeficiency (Cvid), Journal of Isfahan Medical School (2017)

5. Comparison of Various Classifications for Patients With Common Variable Immunodeficiency (Cvid) Using Measurement of B-Cell Subsets, Allergologia et Immunopathologia (2017)

6. Increased Expression of B Lymphocyte Induced Maturation Protein 1 (Blimp1) in Patients With Common Variable Immunodeficiency (Cvid), Iranian Journal of Allergy, Asthma and Immunology (2020)

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Style	Citing Format
MLA	Azizi A, et al.. "Atypical Memory B Cells Increase in the Peripheral Blood of Patients With Breast Cancer Regardless of Lymph Node Involvement." BMC Immunology, vol. 25, no. 1, 2024, pp. -.
APA	Azizi A, Mehdipour F, Samadi M, Rasolmali R, Talei AR, Ghaderi A (2024). Atypical Memory B Cells Increase in the Peripheral Blood of Patients With Breast Cancer Regardless of Lymph Node Involvement. BMC Immunology, 25(1), -.
Chicago	Azizi A, Mehdipour F, Samadi M, Rasolmali R, Talei AR, Ghaderi A. "Atypical Memory B Cells Increase in the Peripheral Blood of Patients With Breast Cancer Regardless of Lymph Node Involvement." BMC Immunology 25, no. 1 (2024): -.
Harvard	Azizi A et al. (2024) 'Atypical Memory B Cells Increase in the Peripheral Blood of Patients With Breast Cancer Regardless of Lymph Node Involvement', BMC Immunology, 25(1), pp. -.
Vancouver	Azizi A, Mehdipour F, Samadi M, Rasolmali R, Talei AR, Ghaderi A. Atypical Memory B Cells Increase in the Peripheral Blood of Patients With Breast Cancer Regardless of Lymph Node Involvement. BMC Immunology. 2024;25(1):-.
BibTex	@article{ author = {Azizi A and Mehdipour F and Samadi M and Rasolmali R and Talei AR and Ghaderi A}, title = {Atypical Memory B Cells Increase in the Peripheral Blood of Patients With Breast Cancer Regardless of Lymph Node Involvement}, journal = {BMC Immunology}, volume = {25}, number = {1}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Azizi A AU - Mehdipour F AU - Samadi M AU - Rasolmali R AU - Talei AR AU - Ghaderi A TI - Atypical Memory B Cells Increase in the Peripheral Blood of Patients With Breast Cancer Regardless of Lymph Node Involvement JO - BMC Immunology VL - 25 IS - 1 SP - EP - PY - 2024 ER -

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