Pomegranate Flower Extract Does Not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats



Jilanchi S¹ ; Nematbakhsh M^{1, 2, 3} ; Mazaheri S¹ ; Talebi A^{1, 4} ; Zolfaghari B^{1, 5} ; Pezeshki Z¹ ; Eshraghijazi F¹ ; Moeini M¹
Source: International Journal of Preventive Medicine Published:2014

Abstract

Background: Nephrotoxicity is the major side-effect of cisplatin (CDDP), and it is reported to be gender-related. We evaluated the effects of pomegranate flower extract (PFE) as an antioxidant on CDDP-induced nephrotoxicity in female rats.; Methods: Twenty-three adult female rats in four groups treated as following. Groups 1 and 2 received PFE at doses of 25 and 50 (mg/kg/day), respectively, for 9 days, and from day 3 on, they also received cisplatin (CDDP) (2.5 mg/kg) daily. Group 3 was treated as group 1 expects saline instead of PFE, and group 4 received PFE (25 mg/kg/day) alone.; Results: Cisplatin alone increased the serum levels of blood urea nitrogen, creatinine, and nitrite; and kidney tissue damage score and kidney weight. However, PFE not only did not ameliorate the induced nephrotoxicity, but also aggravated renal tissue damage.; Conclusions: Pomegranate extract as an antioxidant did not ameliorate CDDP-induced nephrotoxicity in female rats. © 2014, Isfahan University of Medical Sciences(IUMS). All rights reserved.