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Onabotulinum Toxin a Improves Neurogenic Detrusor Overactivity Following Spinal Cord Injury: A Systematic Review and Meta-Analysis Publisher Pubmed

Summary: Meta-analysis shows Botox improves bladder function in spinal cord injury patients with few side effects, offering a promising treatment. #SpinalCordInjury #BladderHealth

Vaheb S1 ; Mokary Y1 ; Ghoshouni H1 ; Mirmosayyeb O1, 2 ; Moases Ghaffary E1 ; Shaygannejad V1, 2 ; Yazdan Panah M3
Authors

Source: Spinal Cord Published:2024


Abstract

Study design: Systematic review and meta-analysis. Objectives: The current study aimed to assess the efficacy and safety of Onabotulinum toxin A (OBTX-A) treatment for neurogenic detrusor overactivity (NDO) in spinal cord injury (SCI) patients. Setting: Iran. Methods: All relevant articles of clinical trials and cohort studies indexed in PubMed/MEDLINE, Embase, Scopus, and Web of Science databases up to September 6, 2022, that addressed OBTX-A treatment for NDO following SCI were included. The quality of eligible studies was evaluated using Cochrane criteria. Also, the weighted mean difference (WMD) was measured with a random-effect model. Results: Regarding the overall efficacy after OBTX-A treatment in the short term, volume per void (VV) (WMD = 118.8, 95% CI: 90.9–146.7, p < 0.01), incontinence-quality of life (IQoL) (WMD = 24.3, 95% CI: 15.8–32.8, p < 0.01), and maximum cystometric capacity (MCC) (WMD = 144.5, 95% CI: 132.3 to 156.7, p < 0.01) significantly increased, while maximum detrusor pressure during storage (MDP) (WMD = –30.5, 95% CI: –35.9 to –25.1, p < 0.01) showed a significant decrease. Furthermore, compared to the placebo group at the 200-unit dose, there was a significant increase in MCC (WMD = 113.5, 95% CI: 84.7 to 142.3, p < 0.01) and a significant decrease in MDP (WMD = −27.2, 95% CI: −39.2 to −15.1, p < 0.01). Urinary tract infection (UTI), hematuria, and autonomic dysreflexia were the most common side effects, occurring at rates of 29.6%, 14.8%, and 13.4%, respectively. Conclusion: Our findings highlighted the effectiveness and safety of OBTX-A as a promising treatment of NDO following SCI. © The Author(s), under exclusive licence to International Spinal Cord Society 2024.
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