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Global, Regional, and National Burden of Spinal Cord Injury, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019 Publisher Pubmed



Safdarian M1, 2 ; Trinka E1, 2, 3, 4, 5 ; Rahimimovaghar V6 ; Thomschewski A1, 2 ; Aali A16 ; Abady GG18 ; Abate SM19 ; Abdallah F20 ; Abedi A21, 22 ; Adane DE24 ; Afzal S25, 26 ; Ahinkorah BO27 ; Ahmad S28 ; Ahmed H29 Show All Authors
Authors
  1. Safdarian M1, 2
  2. Trinka E1, 2, 3, 4, 5
  3. Rahimimovaghar V6
  4. Thomschewski A1, 2
  5. Aali A16
  6. Abady GG18
  7. Abate SM19
  8. Abdallah F20
  9. Abedi A21, 22
  10. Adane DE24
  11. Afzal S25, 26
  12. Ahinkorah BO27
  13. Ahmad S28
  14. Ahmed H29
  15. Amanat N30
  16. Angappan D32
  17. Arabloo J33
  18. Aryannejad A7, 8
  19. Athari SS38
  20. Atreya A39
  21. Azadnajafabad S7
  22. Azzam AY40, 41
  23. Babamohamadi H31
  24. Banik PC42
  25. Bardhan M43, 44
  26. Bashiri A46
  27. Berhie AY50
  28. Bhat AN51
  29. Brown J55, 56
  30. Champs AP58
  31. Charalampous P59
  32. Chukwu IS60
  33. Coberly K61
  34. Dadras O64, 65
  35. Yada DY61
  36. Dai X61, 63
  37. Dandona L45, 61, 66
  38. Dandona R61, 63
  39. Dessalegn FN67
  40. Desta AA68
  41. Dhingra S70
  42. Diao N71
  43. Diaz D73, 74
  44. Dibas M75
  45. Dongarwar D76
  46. Dsouza HL54, 77
  47. Ekholuenetale M78, 79
  48. Nahas NE81
  49. Elhadi M84
  50. Eskandarieh S9
  51. Fagbamigbe AF78, 85
  52. Fares J86
  53. Fatehizadeh A87
  54. Fereshtehnejad SM88, 89
  55. Fischer F90
  56. Franklin RC92
  57. Garg T93
  58. Getachew M94
  59. Ghaffarpasand F47
  60. Gholamrezanezhad A23
  61. Mesgarha MG34
  62. Ghozy S95
  63. Golechha M96
  64. Goleij P97
  65. Graham SM98, 99
  66. Gupta VK100
  67. Haagsma JA59
  68. Hamidi S101
  69. Harlianto NI102, 103
  70. Harorani M104
  71. Hasanian M105
  72. Hassan A20
  73. Hassen MB61, 106
  74. Hoveidaei AH108
  75. Iravanpour F48
  76. Irilouzadian R35, 109
  77. Iwu CCD114
  78. Jacob L115, 116
  79. Jaja CJ117, 118
  80. Joseph N52
  81. Joshua CE119
  82. Jozwiak JJ120
  83. Kadashetti V121
  84. Kandel A122
  85. Kantar RS123, 124
  86. Karaye IM125
  87. Karkhah S126
  88. Khader YS127
  89. Khan EA128
  90. Khan J129
  91. Kashani HRK110
  92. Khonji MS36
  93. Khormali M6
  94. Kim G130, 131
  95. Krishnamoorthy V62, 132
  96. Kumaran SD133
  97. Malekpour MR7
  98. Meretoja TJ134, 135
  99. Mesregah MK136
  100. Mestrovic T61, 137
  101. Micheletti Gomide Nogueira De Sa AC138
  102. Mirahmadi A111
  103. Mirghaderi SP10
  104. Mirza M140
  105. Misganaw A63, 107
  106. Misra S142
  107. Mohammad Y145
  108. Mohammadi E11
  109. Mokdad AH61, 63
  110. Moller H55, 57
  111. Momtazmanesh S7, 12
  112. Moni MA146
  113. Mostafavi E147, 148
  114. Mulita F149, 150
  115. Naghavi M61, 63
  116. Nassereldine H61
  117. Natto ZS72, 151
  118. Nejati K152
  119. Nguyen HLT153
  120. Nguyen VT154
  121. Nogueira De Sa AT139
  122. Olagunju AT155, 156
  123. Olufadewa II79, 157
  124. Omotayo AO158
  125. Owolabi MO80, 159
  126. Patil S160, 161
  127. Pawar S162
  128. Pedersini P163
  129. Petcu IR164
  130. Polinder S59
  131. Pourbaghershahri AM17, 165
  132. Qureshi MF167
  133. Raghav PR143
  134. Rahman M168
  135. Rahnavard N16
  136. Rajabpoursanati A166
  137. Rashidi MM7, 112
  138. Rawaf S169, 170
  139. Roberts NLS171
  140. Saddik B172
  141. Saeed U173, 174
  142. Samadzadeh S91, 175
  143. Samy AM82, 83
  144. Sarveazad A37
  145. Seylani A176
  146. Shafie M13
  147. Shahbandi A12
  148. Sharew MMS69
  149. Sheikhi RA177
  150. Shetty PH53
  151. Yigit A178
  152. Shobeiri P11, 179
  153. Shool S6, 113
  154. Shorofi SA180, 181
  155. Sibhat MM182
  156. Sinaei E49
  157. Singh P141
  158. Singh S144
  159. Solomon Y183
  160. Sotoudeh H184
  161. Tadesse BA185, 186
  162. Umair M187, 188
  163. Tahbaz SV189, 190
  164. Valdez PR191, 192
  165. Venketasubramanian N193, 194
  166. Vu LG195
  167. Wickramasinghe ND196
  168. Zare I197
  169. Yazdanpanah F14, 199
  170. Wu AM198
  171. Zhang ZJ200

Source: The Lancet Neurology Published:2023


Abstract

Background: Spinal cord injury (SCI) is a major cause of health loss due to premature mortality and long-term disability. We aimed to report on the global, regional, and national incidence, prevalence, and years of life lived with disability (YLDs) for SCI from 1990 to 2019, using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods: Using GBD 2019 data pooled in DisMod-MR 2.1, a Bayesian meta-regression tool, we systematically derived numbers and age-standardised rate changes with 95% uncertainty intervals (95% UIs) for the incidence, prevalence, and YLDs for SCI from 1990 to 2019 for the whole world, 21 GBD regions, and 204 countries and territories. We report trends based on age, sex, year, cause of injury, and level of injury. Findings: Globally, 20·6 million (95% UI 18·9 to 23·6) individuals were living with SCI in 2019. The incidence of SCI was 0·9 million (0·7 to 1·2) cases with an estimated 6·2 million (4·5 to 8·2) YLDs. SCI rates increased substantially from 1990 to 2019 for global prevalence (81·5%, 74·2 to 87·1), incidence (52·7%, 30·3 to 69·8), and YLDs (65·4%, 56·3 to 76·0). However, global age-standardised rates per 100 000 population showed small changes in prevalence (5·8%, 2·6 to 9·5), incidence (–6·1%, –17·2 to 1·5), and YLDs (–1·5%, –5·5 to 3·2). Data for 2019 shows that the incidence of SCI increases sharply until age 15–19 years, where it remains reasonably constant until 85 years of age and older. By contrast, prevalence and YLDs showed similar patterns to each other, with one peak at around age 45–54 years. The incidence, prevalence, and YLDs of SCI have consistently been higher in men than in women globally, with a slight and steady increase for both men and women from 1990 to 2019. Between 1990 and 2019, SCI at neck level was more common than SCI below neck level in terms of incidence (492 thousand [354 to 675] vs 417 thousand [290 to 585]), prevalence (10·8 million [9·5 to 13·9] vs 9·7 million [9·2 to 10·4]), and YLDs (4·2 million [3·0 to 5·8] vs 1·9 million [1·3 to 2·5]). Falls (477 thousand [327 to 683] cases) and road injuries (230 thousand [122 to 389] cases) were the two leading causes of SCI globally in 2019. Interpretation: Although age-standardised rates of incidence, prevalence, and YLDs for SCI changed only slightly, absolute counts increased substantially from 1990 to 2019. Geographical heterogeneity in demographic, spatial, and temporal patterns of SCI, at both the national and regional levels, should be considered by policy makers aiming to reduce the burden of SCI. Funding: Bill & Melinda Gates Foundation. © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
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