Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Hypoxia, Stem Cells and Cancer Stem Cells Publisher



M Manian MOSTAFA ; M Taherian MARJAN ; H Nickho HAMID ; A Emaminejad ASIEH ; S Shaverdi SAHAM
Authors

Source: Stem Cell Biology and Regenerative Medicine Published:2024


Abstract

HypoxiaHypoxia, a hallmark of cancer found in 90% of solid tumors, not only limits the efficacy of therapeutic interventions but also contributes to poorer prognoses. The study reveals the critical role of hypoxia-inducible factors (HIFs), particularly HIF-1α and HIF-2α, in regulating pathways associated with EMT, CSC maintenance, metabolic adaptation, quiescence, resistance, and angiogenesis in the TME. Overall, research data in this chapter explain a comprehensive overview of the multifaceted impact of hypoxia on cancer biology, with a focus on its influence on cancer stem cells, tumor progression, and therapy resistance. It covers various aspects of cancer biology, including angiogenesis, tumor vasculature, immune response, cancer metabolism, and stem cell biology, offering insights into the potential therapeutic implications of targeting hypoxia-regulated pathways in cancer treatment. In addition, this research provides a comprehensive overview of the interplay between hypoxiaHypoxia, metabolism, and exosome-mediated signaling in the tumor microenvironment. By focusing on these factors, researchers can develop more effective drug delivery systems for targeting and eliminating cancer stem cells. Finally, the findings highlight the importance of understanding and targeting the hypoxic microenvironment to develop effective approaches for combating cancer stem cells and overcoming treatment resistance. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. The Role of Hypoxia in the Tumor Microenvironment and Development of Cancer Stem Cell: A Novel Approach to Developing Treatment, Cancer Cell International (2021)
2. Expression Analysis of Hif-3Α As a Potent Prognostic Biomarker in Various Types of Human Cancers: A Case of Meta-Analysis, Research in Pharmaceutical Sciences (2022)
3. The Effects of Alk5 Inhibition and Simultaneous Inhibition or Activation of Hif-1Α in Melanoma Tumor Growth and Angiogenesis, Tumor Biology (2023)
Experts (# of related papers)
View all Related Experts
Shaghayegh Haghjooy Javanmard (5)
Reza Nedaeinia (3)
Other Related Docs
4. Acquired Tumor Resistance to Antiangiogenic Therapy: Mechanisms at a Glance, Journal of Research in Medical Sciences (2017)
5. Isfahan Twins Registry (Itr): An Invaluable Platform for Epidemiological and Epigenetic Studies: Design and Methodology of Itr, Twin Research and Human Genetics (2019)
6. Hif-1Α Confers Resistance to Induced Stress in Bone Marrow-Derived Mesenchymal Stem Cells, Archives of Medical Research (2013)
7. Comparing the Effect of Emotional Freedom Technique on Sleep Quality and Happiness of Women Undergoing Breast Cancer Surgery in Military and Nonmilitary Families: A Quasi-Experimental Multicenter Study, Perspectives in Psychiatric Care (2022)
8. Immune Checkpoint Inhibitors As Mediators for Immunosuppression by Cancer-Associated Fibroblasts: A Comprehensive Review, Frontiers in Immunology (2022)
9. Cutting Edge: Metabolic Immune Reprogramming, Reactive Oxygen Species, and Cancer, Journal of Cellular Physiology (2021)
10. A Quick Review of Redox State in Cancer: Focus to Bladder, The Gulf journal of oncology (2020)
11. Association Between Adhering to a Dietary Approach to Stop Hypertension and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis, BMC Gastroenterology (2025)
12. Nrf2 Signaling Pathway in Trace Metal Carcinogenesis: A Cross-Talk Between Oxidative Stress and Angiogenesis, Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology (2022)
13. Intersecting Pathways: The Role of Hybrid E/M Cells and Circulating Tumor Cells in Cancer Metastasis and Drug Resistance, Drug Resistance Updates (2024)
14. Differential Effects of Β-Hydroxybutyrate and Α-Ketoglutarate on Hct-116 Colorectal Cancer Cell Viability Under Normoxic and Hypoxic Low-Glucose Conditions: Exploring the Role of Src, Hif1α, Acat1, and Sirt2 Genes, Molecular Genetics and Genomics (2025)
15. Tumor-Associated Macrophages and Epithelial–Mesenchymal Transition in Cancer: Nanotechnology Comes Into View, Journal of Cellular Physiology (2018)
16. Immunotherapies Targeting Tumor Vasculature: Challenges and Opportunities, Frontiers in Immunology (2023)
17. Effect of the Number of Negative Lymph Nodes Removed on the Survival and Recurrence Rate After Primary Surgery in Patients With Ovarian Cancer: A Multi-Center Retrospective Cohort Study, Indian Journal of Surgical Oncology (2024)
18. Immune Evader Cancer Stem Cells Direct the Perspective Approaches to Cancer Immunotherapy, Stem Cell Research and Therapy (2022)
19. Recent Advances in Nanomaterials Development for Nanomedicine and Cancer, ACS Applied Bio Materials (2021)
20. Discovery of Novel Direct Small-Molecule Inhibitors Targeting Hif-2Α Using Structure-Based Virtual Screening, Molecular Dynamics Simulation, and Mm-Gbsa Calculations, Molecular Diversity (2024)