Synthesis, Analysis and Cytotoxic Evaluation of Some Hydroxypyridinone Derivatives on Hela and K562 Cell Lines

Synthesis, Analysis and Cytotoxic Evaluation of Some Hydroxypyridinone Derivatives on Hela and K562 Cell Lines

Saghaie L¹ ; Sadeghialiabadi H¹ ; Ashaehshoar M¹

Show Affiliations

1. Department of Pharmaceutical Chemistry AndIsfahan Pharmaceutical Research Centre, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Research in Pharmaceutical Sciences Published:2013

Abstract

range of iron bidentae ligands containing the chelating moiety 3-hydroxypyridin-4-ones (HPOs) have been synthesized via a single or a three-step synthetic pathway. In the single-step reaction, maltol was directly reacted by suitable primary amine and in the second synthetic method; benzylated maltol was reacted with related amines to give 1-substuted-2-methyl-3- benzyloxypyridin-4-one derivatives. Finally, removal of the benzyl group under acidic conditions was performed by catalytic hydrogenation to yield the favored bidentate chelators as HCl salt. The partition coefficient of the free ligands and their iron (III) complexes between an aqueous phase buffered at pH 7.4 and 1-octanol were also determined. The cytotoxic effects of these iron chelators against HeLa and K562 cell lines were evaluated using MTT assay and the results showed that cytotoxicity was closely related to the lipophilicity of compounds so that the most lipophilic compound (4g) revealed the highest activity and compound 4e as a more hydrophilic agent (Kpart; 0.05) showed the lowest cytotoxic effect.

Related Docs

View other Related Docs

1. Hydroxypyridinone Derivatives: Synthesis and Cytotoxic Evaluation, Journal of Reports in Pharmaceutical Sciences (2013)

2. Synthesis and Biological Evaluation of Bidentate 3-Hydroxypyridin-4-Ones Iron Chelating Agents, Research in Pharmaceutical Sciences (2011)

3. Synthesis of Polymers Containing 3-Hydroxypyridin-4-One Bidentate Ligands for Treatment of Iron Overload, Research in Pharmaceutical Sciences (2015)

4. Evaluation of the Cytotoxic Effect of Hydroxypyridinone Derivatives on Hct116 and Sw480 Colon Cancer Cell Lines, Pharmaceutical Chemistry Journal (2019)

5. A New Spectrophotometric Method for Direct Determination of Iron (Iii) in Serum, Daru (2008)

6. Computer-Aided Design of Novel Antibacterial 3-Hydroxypyridine-4-Ones: Application of Qsar Methods Based on the Molmap Approach, Journal of Computer-Aided Molecular Design (2012)

7. Cardioprotection Potential of Some Hydroxypyridine Iron Chelators Against H2o2-Induced H9c2 Cell Injury, Turkiye Klinikleri Cardiovascular Sciences (2017)

8. Stepwise Mlr and Pcr Qsar Study of the Pharmaceutical Activities of Antimalarial 3-Hydroxypyridinone Agents Using B3lyp/6-311++G* *Descriptors, Medicinal Chemistry Research (2013)

Experts (# of related papers)

View all Related Experts

Lotfollah Saghaie Dehkordi (11)

Afshin Fassihi (4)

Style	Citing Format
MLA	Saghaie L, Sadeghialiabadi H, Ashaehshoar M. "Synthesis, Analysis and Cytotoxic Evaluation of Some Hydroxypyridinone Derivatives on Hela and K562 Cell Lines." Research in Pharmaceutical Sciences, vol. 8, no. 3, 2013, pp. 185-195.
APA	Saghaie L, Sadeghialiabadi H, Ashaehshoar M (2013). Synthesis, Analysis and Cytotoxic Evaluation of Some Hydroxypyridinone Derivatives on Hela and K562 Cell Lines. Research in Pharmaceutical Sciences, 8(3), 185-195.
Chicago	Saghaie L, Sadeghialiabadi H, Ashaehshoar M. "Synthesis, Analysis and Cytotoxic Evaluation of Some Hydroxypyridinone Derivatives on Hela and K562 Cell Lines." Research in Pharmaceutical Sciences 8, no. 3 (2013): 185-195.
Harvard	Saghaie L, Sadeghialiabadi H, Ashaehshoar M (2013) 'Synthesis, Analysis and Cytotoxic Evaluation of Some Hydroxypyridinone Derivatives on Hela and K562 Cell Lines', Research in Pharmaceutical Sciences, 8(3), pp. 185-195.
Vancouver	Saghaie L, Sadeghialiabadi H, Ashaehshoar M. Synthesis, Analysis and Cytotoxic Evaluation of Some Hydroxypyridinone Derivatives on Hela and K562 Cell Lines. Research in Pharmaceutical Sciences. 2013;8(3):185-195.
BibTex	@article{ author = {Saghaie L and Sadeghialiabadi H and Ashaehshoar M}, title = {Synthesis, Analysis and Cytotoxic Evaluation of Some Hydroxypyridinone Derivatives on Hela and K562 Cell Lines}, journal = {Research in Pharmaceutical Sciences}, volume = {8}, number = {3}, pages = {185-195}, year = {2013} }
RIS	TY - JOUR AU - Saghaie L AU - Sadeghialiabadi H AU - Ashaehshoar M TI - Synthesis, Analysis and Cytotoxic Evaluation of Some Hydroxypyridinone Derivatives on Hela and K562 Cell Lines JO - Research in Pharmaceutical Sciences VL - 8 IS - 3 SP - 185 EP - 195 PY - 2013 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract