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Association Between Dlco Index and the Severity of Heart Failure: A Cross-Sectional Study Publisher Pubmed



Izadi S1 ; Esmaili S2 ; Emami S3 ; Izadi S1 ; Eskandari M2 ; Yadollahzadeh M1 ; Saleh M5 ; Khavandegar A6 ; Bakhtiyari M7
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Firoozgar General Hospital, Iran University of Medical Sciences, Iran
  2. 2. Residence of Internal Medicine, Firoozgar Medical & Educational Hospital, Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of cardiology, School of Medicine, Firoozgar General Hospital, Iran University of Medical Sciences, Iran
  4. 4. School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Shariati hospital, Tehran, Iran
  6. 6. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
  7. 7. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran

Source: Acta Cardiologica Published:2023


Abstract

Background: The prognostic role of diffusing capacity of the lung for carbon monoxide (DLCO) in heart failure has not been thoroughly investigated. Therefore, this study aimed to evaluate DLCO variation in different systolic and diastolic heart failure stages. Methods: This was a prospective cross-sectional study on 51 patients with systolic (reduced LVEF) or diastolic (preserved LVEF) chronic heart failure (CHF). All patients underwent a standard DLCO test. The associations between the severity of heart failure and reduced carbon monoxide transfer factor (TLCO), carbon monoxide transfer coefficient (KCO), and alveolar volume (VA) were investigated. Data were analysed using SPSS software version 16. p-Values below 0.05 were considered statistically significant. Results: The mean age of participants was 59.29 ± 14.91 years, with 72% of the study population being male. Systolic heart failure was observed in 47% of patients, diastolic heart failure in 18%, and a mixed systolic and diastolic pattern in 35%. There were significant differences between TLCO percentage in patients with CHF types and the New York Heart Association (NYHA) functional classes (p = 0.042). Overall, an ejection fraction (EF) of less than 25% correlated with 3%, 53%, and 0.78 declines in TLCO, KCO%, and KCO index, respectively. Conclusion: Despite the lack of statistically significant differences between DLCO indices and CHF severity, decreased DLCO parameters correlated with reduced EF. Therefore, DLCO testing might be helpful to predict HF severity. © 2022 Belgian Society of Cardiology.
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