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Sex Differences in Cerebral Venous Sinus Thrombosis After Adenoviral Vaccination Against Covid-19 Publisher Pubmed



Scutelnic A1 ; Van De Munckhof A2 ; Krzywicka K2 ; Van Kammen MS2 ; Lindgren E3, 4 ; Cordonnier C5 ; Kleinig TJ6 ; Field TS7 ; Poli S8 ; Lemmens R9 ; Middeldorp S10 ; Aaron S11 ; Borhanihaghighi A12 ; Arauz A13 Show All Authors
Authors
  1. Scutelnic A1
  2. Van De Munckhof A2
  3. Krzywicka K2
  4. Van Kammen MS2
  5. Lindgren E3, 4
  6. Cordonnier C5
  7. Kleinig TJ6
  8. Field TS7
  9. Poli S8
  10. Lemmens R9
  11. Middeldorp S10
  12. Aaron S11
  13. Borhanihaghighi A12
  14. Arauz A13
  15. Kremer Hovinga JA14
  16. Gunther A15
  17. Putaala J16
  18. Wasay M17
  19. Conforto AB18
  20. De Sousa DA19
  21. Jood K3, 4
  22. Tatlisumak T3, 4
  23. Ferro JM20
  24. Coutinho JM2
  25. Arnold M1
  26. Heldner MR1
  27. Antonenko K1
  28. Mbroh J8
  29. Brodard J14
  30. Hooshmandi E12
  31. Dizonno V21
  32. Devroye A9
  33. Ciccone A22
  34. Wittstock M23
  35. Zimmermann J23
  36. Bode FJ24
  37. Skjelland M25
  38. Duan J26
  39. Hiltunen S27
  40. Zuurbier SM2
  41. Petruzzellis M28
  42. Sharma AR29
  43. Ghoreishi A30
  44. Elkady A31
  45. Negro A32
  46. Gutschalk A33
  47. Schoenenberger S33
  48. Nagel S33
  49. Buture A34
  50. Cervera A35
  51. Paiva Nunes A36
  52. Romina Montane Banos A37
  53. Tiede A38
  54. Puthuppallil A39
  55. Tuladhar AM40
  56. Mengel A8
  57. Medina A41
  58. Hellstrom Vogel A42
  59. Tawa A43
  60. Aujayeb A44
  61. Ramasamy B45
  62. Casolla B46
  63. Lim Alvin Chew B47
  64. Ziaadini B48
  65. Varkey Maramattom B49
  66. Buck B50
  67. Zanferrari C51
  68. Garciaesperon C52
  69. Vayne C53
  70. Legault C54
  71. Jacobi C55
  72. Pfrepper C56
  73. Pelz J56
  74. Wahl C57
  75. Kern R57
  76. Tracol C58
  77. Soriano C59
  78. Guisadoalonso D60
  79. Bougon D61
  80. Bal D62
  81. Sergio Zimatore D63
  82. Michalski D56
  83. Blacquiere D62
  84. Johansson E3, 64, 152
  85. Cuadradogodia E65
  86. Sadeghihokmabadi E66
  87. Carrera E67
  88. De Maistre E68
  89. Saxhaug Kristoffersen E69
  90. Bonneville F70
  91. Geeraerts T70
  92. Vuillier F71
  93. Giammello F72
  94. Donofrio F73
  95. Grillo F74
  96. Caparros F75
  97. Susen S75
  98. Maier F76
  99. Tsivgoulis G77
  100. Gulli G78
  101. Frisullo G79
  102. Franchineau G80
  103. Cangur H81
  104. Katzberg H82
  105. Mozhdehipanah H83
  106. Sibon I84
  107. Baharoglu MI85
  108. Masjuan J86
  109. Brar J87
  110. Payen JF88
  111. Burrow J35
  112. Fernandes J89
  113. Octavio Lopez Esparza J90
  114. Oen J91
  115. Schouten J92
  116. Ng K93
  117. Chatterton S93
  118. Wronski M93
  119. Althaus K94
  120. Garambois K95
  121. Derex L96
  122. Puy L75
  123. Poorsaadat L97
  124. Valler L98
  125. Januzi De Almeida Rocha L99
  126. Humbertjean L100
  127. Lebrato Hernandez L101
  128. Murillobonilla L102
  129. Kellermair L103
  130. Morin Martin M104
  131. Sofia Cotelli M105
  132. Hernandez Perez M106
  133. Zedde M107
  134. Carvalho Dias M108
  135. Dubois MC109
  136. Carvalho M110
  137. Ghiasian M111
  138. Umaiorubahan M112
  139. Kumar Karunakaran R112
  140. Roozbeh M113
  141. Romoli M114
  142. Miranda M115
  143. Saadatnia M116
  144. Bandettini Di Poggio M117
  145. Scholz MJ118
  146. Kahnis R118
  147. Almasidooghaee M119
  148. Hoseininejad Mir N120
  149. Ichaporia NR121
  150. Kumar Paramasivan N122
  151. Erat Sreedharan S122
  152. Sylaja PN122
  153. Raposo N123
  154. Fadakar N12
  155. Kruyt N124
  156. Detante O125
  157. Cuisenier P125
  158. Huet O126
  159. Sharma P127
  160. Candelaresi P128
  161. Scoppettuolo P129
  162. Reiner P130
  163. Nemati R131
  164. Vieira R132
  165. Goh R6
  166. Murphy S34
  167. Timsit S133
  168. Coutts S134
  169. Sharma SS135
  170. Bal S135
  171. Kaul S136
  172. Karapanayiotides T137
  173. Cox T138
  174. Gattringer T139
  175. Mathew T140
  176. Bartsch T141
  177. Shaygannejad V142
  178. Garciatalavera V143
  179. Palma V144
  180. Arslan Y145
  181. Mirzaasgari Z146
  182. Yavari Z147
  183. Zamani Z148
  184. Bakchoul T149
  185. Levi M150
  186. Van Gorp ECM151

Source: European Stroke Journal Published:2023


Abstract

Introduction: Cerebral venous sinus thrombosis associated with vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is a severe disease with high mortality. There are few data on sex differences in CVST-VITT. The aim of our study was to investigate the differences in presentation, treatment, clinical course, complications, and outcome of CVST-VITT between women and men. Patients and methods: We used data from an ongoing international registry on CVST-VITT. VITT was diagnosed according to the Pavord criteria. We compared the characteristics of CVST-VITT in women and men. Results: Of 133 patients with possible, probable, or definite CVST-VITT, 102 (77%) were women. Women were slightly younger [median age 42 (IQR 28–54) vs 45 (28–56)], presented more often with coma (26% vs 10%) and had a lower platelet count at presentation [median (IQR) 50x109/L (28–79) vs 68 (30–125)] than men. The nadir platelet count was lower in women [median (IQR) 34 (19–62) vs 53 (20–92)]. More women received endovascular treatment than men (15% vs 6%). Rates of treatment with intravenous immunoglobulins were similar (63% vs 66%), as were new venous thromboembolic events (14% vs 14%) and major bleeding complications (30% vs 20%). Rates of good functional outcome (modified Rankin Scale 0-2, 42% vs 45%) and in-hospital death (39% vs 41%) did not differ. Discussion and conclusions: Three quarters of CVST-VITT patients in this study were women. Women were more severely affected at presentation, but clinical course and outcome did not differ between women and men. VITT-specific treatments were overall similar, but more women received endovascular treatment. © European Stroke Organisation 2023.
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