The Importance of Snps at Mirna Binding Sites As Biomarkers of Gastric and Colorectal Cancers: A Systematic Review Publisher

Summary: Might gene tweaks unlock gut cancer early warnings? Systematic review spots 20 SNPs altering miRNA binding in 16 miRNAs, tying to progression in gastric/colorectal cases—offering SNP-miRNA profiles for better prognosis and detection. #GastrointestinalCancer #Biomarkers

Hajibabaie F¹ ; Abedpoor N² ; Assareh N¹ ; Tabatabaiefar MA^{3, 4} ; Shariati L^{5, 6} ; Zarrabi A⁷
Source: Journal of Personalized Medicine Published:2022

Abstract

Dysregulated mRNA–miRNA profiles might have the prospective to be used for early diagnosis of gastrointestinal cancers, estimating survival, and predicting response to treatment. Here, a novel biomarker based on miRNAs binding to mRNAs in single nucleotide polymorphism (SNP) sites related to gastrointestinal cancers is introduced that could act as an early diagnosis. The electronic databases used for the recruiting published articles included EMBASE, SCOPUS, Web of Science, and PubMed, based on MESH keywords and PRISMA methodology. Based on the considered criteria, different experimental articles were reviewed, during which 15 studies with the desired criteria were collected. Accordingly, novel biomarkers in prediction, early prognosis, and diagnosis of gastrointestinal cancers were highlighted. Moreover, it was found that 20 SNP sites and 16 miRNAs were involved in gastrointestinal cancers, with altered expression patterns associated with clinicopathological and demographic data. The results of this systematic study revealed that SNPs could affect the binding of miRNAs in the SNP sites that might play a principal role in the progression, invasion, and susceptibility of gastrointestinal cancers. In addition, it was found that the profiles of SNPs and miRNAs could serve as a convenient approach for the prognosis and diagnosis of gastric and colorectal cancers. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.