Microrna Profiles in Critically Ill Patients Publisher Pubmed

Summary: MicroRNAs show promise as biomarkers for critical illness, aiding diagnosis and treatment, review suggests. #CriticalCare #Biomarkers

Alikiaii B¹ ; Bagherniya M^{2, 3} ; Askari G^{2, 3} ; Rajendram R^{4, 5} ; Sahebkar A^{6, 7, 8}
Source: Current Medicinal Chemistry Published:2024

Abstract

The use of biomarkers to expedite diagnosis, prognostication, and treatment could significantly improve patient outcomes. The early diagnosis and treatment of critical illnesses can greatly reduce mortality and morbidity. Therefore, there is great interest in the discovery of biomarkers for critical illnesses. Micro-ribonucleic acids (miRNAs) are a highly conserved group of non-coding RNA molecules. They regulate the expression of genes involved in several developmental, physiological, and pathological process-es. The characteristics of miRNAs suggest that they could be versatile biomarkers. Assay panels to measure the expression of several miRNAs could facilitate clinical decision--making for a range of diseases. We have, in this paper, reviewed the current understanding of the role of miRNAs as biomarkers in critically ill patients. © 2024 Bentham Science Publishers.