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Microrna Dysregulation and Its Impact on Apoptosis-Related Signaling Pathways in Myelodysplastic Syndrome Publisher Pubmed



Hedayati N1 ; Safaei Naeini M2 ; Ale Sahebfosoul MM2 ; Mafi A3, 4 ; Eshaghi Milasi Y3 ; Rizaneh A2 ; Nabavi N5 ; Farahani N6 ; Alimohammadi M7 ; Ghezelbash B2
Authors
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Authors Affiliations
  1. 1. School of Medicine, Iran University of Medical Science, Tehran, Iran
  2. 2. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Independent Researcher, Victoria, BC, Canada
  6. 6. Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2024


Abstract

Myelodysplastic syndrome (MDS) holds a unique position among blood cancers, encompassing a spectrum of blood-related disorders marked by impaired maturation of blood cell precursors, bone marrow abnormalities, genetic instability, and a higher likelihood of progressing to acute myeloid leukemia. MicroRNAs (miRNAs), short non-coding RNA molecules typically 18–24 nucleotides in length, are known to regulate gene expression and contribute to various biological processes, including cellular differentiation and programmed cell death. Additionally, miRNAs are involved in many aspects of cancer development, influencing cell growth, transformation, and apoptosis. In this study, we explore the impact of microRNAs on cellular apoptosis in MDS. © 2024 Elsevier GmbH
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