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Antihypertensive Effect of Iranian Crataegus Curvisepala Lind.: A Randomized, Double-Blind Study Pubmed



Asgary S1, 3 ; Naderi GH1 ; Sadeghi M1 ; Kelishadi R1 ; Amiri M2
Authors

Source: Drugs under Experimental and Clinical Research Published:2004


Abstract

The aim of the present study was to investigate the potential antihypertensive effects of extracts of the flavonoid-rich Iranian flower, Crataegus curvisepala Lind., a member of the Rosaceae family. The hydroalcoholic extract of the leaves and flowers were studied in a double-blind, placebo-controlled clinical trial to determine its effects. A total of 92 men and women with primary mild hypertension, aged 40-60 years, were selected and divided randomly into two groups, receiving either hydroalcoholic extract of C. curvisepala Lind. or placebo three times daily for more than 4 months. Blood pressure (BP) was measured each month. Statistical analysis was carried out using Student's t-test. The results obtained showed a significant decrease in both systolic and diastolic BP after 3 months (p < 0.05). C. curvisepala has a time-dependent antihypertensive effect.
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