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Antihypertensive and Antioxidant Effects of Protocatechuic Acid in Deoxycorticosterone Acetate-Salt Hypertensive Rats Publisher Pubmed



Safaeian L1 ; Emami R1 ; Hajhashemi V1 ; Haghighatian Z2
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Biomedicine and Pharmacotherapy Published:2018


Abstract

Protocatechuic acid (PCA) is a natural antioxidant with beneficial cardiovascular properties. In this study, the effect of supplementation with PCA was investigated in deoxycorticosterone acetate (DOCA)-salt hypertension. Male Wistar rats received DOCA (25 mg/kg, s.c.) twice weekly and 1% NaCl in drinking water and simultaneously treated with PCA (50, 100 and 200 mg/kg, p.o.) for 4 weeks. Systolic blood pressure (SBP) was detected using tail-cuff method. Electrolytes including Na+, K+ and chloride, catalase activity, glutathione, total antioxidant capacity, malondialdehyde (MDA) and hydroperoxides concentration were measured in serum samples. Body and organs weight, water intake and, kidney and heart histopathology were also evaluated. Administration of PCA reversed the changes caused by DOCA-salt approximately at all doses. At the lowest dose, PCA significantly decreased SBP (132.5 ± 4.0 vs 152.3 ± 4.5 mmHg, P <.05), serum sodium (138.5 ± 1.52 vs 141 ± 1.50, P <.05) and chloride level (101.6 ± 1.47 vs 110 ± 1.39, P <.01) and raised serum potassium level (3.8 ± 0.09 vs 3.1 ± 0.17, P <.05) compared with DOCA-salt hypertensive rats. PCA increased serum catalase activity, total antioxidant capacity and glutathione concentration and reduced MDA and hydroperoxides levels. PCA also improved organ weight changes, reduced water intake and moderately prevented histopathological changes of kidney and heart upon DOCA-salt administration. The present study indicates the antihypertensive and antioxidant effects of PCA against DOCA-salt hypertension. © 2018 Elsevier Masson SAS
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